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Electronic Supplementary Information Phosphocholine-decorated Superparamagnetic Iron Oxide Nanoparticles: Defining the Structure and Probing in Vivo Application. Small Angle X-ray Scattering (saxs)
| Content Provider | Semantic Scholar |
|---|---|
| Abstract | SPIONs were synthesized through thermal decomposition method. 1 In detail 0.355 g of iron(III) 99%) and 10 ml of diphenyl ether (C 12 H 10 O, 99%), all purchased from Sigma Aldrich, were mixed together in a three neck flask. The solution was heated at 200 °C under argon atmosphere and vigorous stirring. After 2 h at reflux, the flask was removed from the heater and cooled to room temperature. The 1,2-hexadecanediol is chosen as reducing agent to convert the iron(III) salts in Fe 3 O 4 oxide, which contains both Fe(II) and Fe (III), while oleic acid and oleylamine are introduced as stabilizing agents to prevent nanoparticle aggregation. At the end of the synthesis, in order to allow the removal of undesired components, the suspension was treated with ~ 10 ml of ethanol and, after centrifugation at 7000 rpm for 20 min, the nanoparticles were obtained as a solid precipitate and then dispersed with cyclohexane. Small Angle X-ray Scattering measurements at room temperature were performed at the beam line I22 of Diamond Light Source. The instrumentation associated with this beam line ensures high flux and brilliance, as well as high resolution and minimum beam divergence. The beam line operated at energy corresponding to 12.8 keV and a wavelength of 1 Å, while the detector was positioned at a distance of 6 m from the sample. This configuration allowed collecting data in the q range corresponding to 0.007-0.240 Å-1 , which resulted to be appropriate in order to have information on nanoparticle structure. The raw data were then corrected for the background. Detector efficiency correction, radial average and transformation to absolute scattering cross sections were made d d using collagen as standard. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://www.rsc.org/suppdata/c5/nr/c5nr08486e/c5nr08486e1.pdf |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
