NDLI: Genotoxicity of metal oxide nanomaterials: review of recent data and discussion of possible mechanisms

Content Provider	Royal Society of Chemistry (RSC)
Author	Golbamaki, Nazanin Cassano, Antonio Cronin, Mark T. D. Benfenati, Emilio Robinson, Richard L. Marchese Leszczynski, Jerzy Rasulev, Bakhtiyor
Copyright Year	2015
Abstract	Nanotechnology has rapidly entered into human society, revolutionized many areas, including technology, medicine and cosmetics. This progress is due to the many valuable and unique properties that nanomaterials possess. In turn, these properties might become an issue of concern when considering potentially uncontrolled release to the environment. The rapid development of new nanomaterials thus raises questions about their impact on the environment and human health. This review focuses on the potential of nanomaterials to cause genotoxicity and summarizes recent genotoxicity studies on metal oxide/silica nanomaterials. Though the number of genotoxicity studies on metal oxide/silica nanomaterials is still limited, this endpoint has recently received more attention for nanomaterials, and the number of related publications has increased. An analysis of these peer reviewed publications over nearly two decades shows that the test most employed to evaluate the genotoxicity of these nanomaterials is the comet assay, followed by micronucleus, Ames and chromosome aberration tests. Based on the data studied, we concluded that in the majority of the publications analysed in this review, the metal oxide (or silica) nanoparticles of the same core chemical composition did not show different genotoxicity study calls (i.e. positive or negative) in the same test, although some results are inconsistent and need to be confirmed by additional experiments. Where the results are conflicting, it may be due to the following reasons: (1) variation in size of the nanoparticles; (2) variations in size distribution; (3) various purities of nanomaterials; (4) variation in surface areas for nanomaterials with the same average size; (5) differences in coatings; (6) differences in crystal structures of the same types of nanomaterials; (7) differences in size of aggregates in solution/media; (8) differences in assays; (9) different concentrations of nanomaterials in assay tests. Indeed, due to the observed inconsistencies in the recent literature and the lack of adherence to appropriate, standardized test methods, reliable genotoxicity assessment of nanomaterials is still challenging.
Starting Page	2154
Ending Page	2198
Page Count	45
File Format	HTM / HTML PDF
ISSN	20403364
Volume Number	7
Issue Number	6
Journal	Nanoscale
DOI	10.1039/c4nr06670g
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Standardized test Ames Ames Research Center Chromosome abnormality The Rapid Development Genotoxicity Micronucleus Nanomaterials Nanotechnology Silicon dioxide Comet assay
Content Type	Text
Resource Type	Article
Subject	Nanoscience and Nanotechnology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Genotoxicity induced by medicinal plants

Genotoxicity Assessment of Erythritol by Using Short-term Assay.

Genotoxicity evaluation of water soil leachates by Ames test, comet assay, and preliminary Tradescantia micronucleus assay

Genotoxicity Studies on Carrageenan: Short-term In Vitro Assays.

Genotoxicity Profile of Azidothymidine In Vitro

In Vitro Genotoxicity Assessment of Functional Ingredients: Betaine, Choline, and Taurine

Assessing the genotoxicity of two commonly occurring byproducts of water disinfection: chloral hydrate and bromal hydrate

Recent advances in in vivo genotoxicity testing: prediction of carcinogenic potential using comet and micronucleus assay in animal models.

The Comet Assay: Tails of the (Un)expected. Use of the comet assay in pharmaceutical development.

Genotoxicity of metal oxide nanomaterials: review of recent data and discussion of possible mechanisms

Similar Documents

Genotoxicity induced by medicinal plants

Genotoxicity Assessment of Erythritol by Using Short-term Assay.

Genotoxicity evaluation of water soil leachates by Ames test, comet assay, and preliminary Tradescantia micronucleus assay

Genotoxicity Studies on Carrageenan: Short-term In Vitro Assays.

Genotoxicity Profile of Azidothymidine In Vitro

In Vitro Genotoxicity Assessment of Functional Ingredients: Betaine, Choline, and Taurine

Assessing the genotoxicity of two commonly occurring byproducts of water disinfection: chloral hydrate and bromal hydrate

Recent advances in in vivo genotoxicity testing: prediction of carcinogenic potential using comet and micronucleus assay in animal models.

The Comet Assay: Tails of the (Un)expected. Use of the comet assay in pharmaceutical development.

Genotoxicity of metal oxide nanomaterials: review of recent data and discussion of possible mechanisms