NDLI: Combining nanotechnology with current biomedical knowledge for the vascular imaging and treatment of atherosclerosis

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Molecular BioSystems Vol - 6 Issue - 2

Molecular BioSystems Vol -5

Molecular BioSystems Vol -4

Molecular BioSystems Vol -3

Molecular BioSystems Vol -2

Combining nanotechnology with current biomedical knowledge for the vascular imaging and treatment of atherosclerosis

Content Provider	Royal Society of Chemistry (RSC)
Author	Grau-Olivares, M. Krupinski, J. Slevin, M. Ramis, M. Badimon, L. Morrison, M. Sendra, J.
Copyright Year	2010
Abstract	Activation of vasa vasorum (the microvessels supplying the major arteries) at specific sites in the adventitia initiates their proliferation or ‘angiogenesis’ concomitant with development of atherosclerotic plaques. Haemorrhagic, leaky blood vessels from unstable plaques proliferate abnormally, are of relatively large calibre but are immature neovessels poorly invested with smooth muscle cells and possess structural weaknesses which may contribute to instability of the plaque by facilitation of inflammatory cell infiltration and haemorrhagic complications. Weak neovascular beds in plaque intima as well as activated adventitial blood vessels are potential targets for molecular imaging and targeted drug therapy, however, the majority of tested, currently available imaging and therapeutic agents have been unsuccessful because of their limited capacity to reach and remain stably within the target tissue or cells in vivo. Nanoparticle technology together with magnetic resonance imaging has allowed the possibility of imaging of neovessels in coronary or carotid plaques, and infusion of nanoparticle suspensions using infusion catheters or implant-based drug delivery represents a novel and potentially much more efficient option for treatment. This review will describe the importance of angiogenesis in mediation of plaque growth and development of plaque instability and go on to investigate the possibility of future design of superparamagnetic/perfluorocarbon-derived nanoparticles for imaging of the vasculature in this disease or which could be directed to the adventitial vasa vasorum or indeed intimal microvessels and which can release active payloads directed against primary key external mitogens and intracellular signalling molecules in endothelial cells responsible for their activation with a view to inhibition of angiogenesis.
Starting Page	444
Ending Page	450
Page Count	7
File Format	HTM / HTML PDF
ISSN	1742206X
Volume Number	6
Issue Number	3
Journal	Molecular BioSystems
DOI	10.1039/b916175a
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Adventitia Angiogenesis Magnetic resonance imaging Nanoparticle Vasa vasorum Haemorrhagic Smooth muscle tissue Drug delivery Superparamagnetism Unique key Common carotid artery Endothelium
Content Type	Text
Resource Type	Article
Subject	Molecular Biology Biotechnology

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Arterial intimal hyperplasia after occlusion of the adventitial vasa vasorum in the pig.

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Vasa Vasorum Angiogenesis: Key Player in the Initiation and Progression of Atherosclerosis and Potential Target for the Treatment of Cardiovascular Disease

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Imaging of carotid artery inflammatory plaques with superparamagnetic nanoparticles and an external magnet collar

Recanalisation of the internal carotid artery via the vasa vasorum after coil occlusion.

The Adventitia: Essential Role in Pulmonary Vascular Remodeling

Combining nanotechnology with current biomedical knowledge for the vascular imaging and treatment of atherosclerosis

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Modified C-Reactive Protein is Expressed in Adventitia and Intimal Neovessels from Complicated Regions of Unstable Carotid Plaques

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