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Arterial intimal hyperplasia after occlusion of the adventitial vasa vasorum in the pig.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Barker, Stephen George Edward Talbert, Alison W. Cottam, Simon Baskerville, Peter Martin, John |
| Copyright Year | 1993 |
| Abstract | Oxygenation of the arterial wall is provided by diffusion of oxygen outward from the main vessel lumen and inward from the adventitial vasa vasorum. In a group of four Yucatan miniature pigs the oxygenation profiles across the superficial femoral arteries were recorded by polarographic oxygen microelectrodes. The profiles obtained suggested a relatively poorly oxygenated media (a trough value of approximately 25% that of the intimal oxygenation) with a progressive rise in oxygenation toward the intimal and adventitial surfaces. In four other survival experiments, occlusion of the adventitial vasa vasorum by flush ligation of the arterial branches that supply them resulted in the production of a focal, intimal hyperplastic lesion that was absent in control vessels (intimal to medial ratios [mean +/- SEM] of 0.053 +/- 0.008, n = 8, p < 0.001 and 0.013 +/- 0.001, n = 8, respectively). By electron microscopy this lesion was seen to be composed mainly of smooth muscle cells. This evidence would support the hypothesis that arterial wall hypoxia may be involved in the initiation of intimal hyperplasia. It is proposed that human atherosclerosis may be initiated by occlusion of the vasa vasorum and concomitant hypoxia. |
| Starting Page | 769 |
| Ending Page | 817 |
| Page Count | 49 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://atvb.ahajournals.org/content/atvbaha/13/1/70.full.pdf |
| Alternate Webpage(s) | http://atvb.ahajournals.org/content/atvbaha/13/1/70.full.pdf?origin=publication_detail |
| PubMed reference number | 8422341v1 |
| Volume Number | 13 |
| Issue Number | 1 |
| Journal | Arteriosclerosis and thrombosis : a journal of vascular biology |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Atherosclerosis Blood Vessel Tissue Cell Respiration Electron Microscopy Endometrial Hyperplasia Flushing Hypoxia Kimura Disease Ligation Muscle Cells Myocytes, Smooth Muscle Oxygen Smooth muscle (tissue) Structure of femoral artery Structure of lumen of body system Structure of vasa vasorum |
| Content Type | Text |
| Resource Type | Article |
