NDLI: Protein intrinsic disorder and oligomericity in cell signaling

Please wait, while we are loading the content...

Probing native lignin macromolecular configuration in Arabidopsis thaliana in specific cell wall types: Further insights into limited substrate degeneracy and assembly of the lignins of ref8, fah 1–2 and C4H::F5H lines

A systems perspective of host–pathogen interactions: predicting disease outcome in tuberculosis

Stochastic kinetic model of two component system signalling reveals all-or-none, graded and mixed mode stochastic switching responses

Meta-analysis of genome regulation and expression variability across hundreds of environmental and genetic perturbations in fission yeast

An alternative strategy to synthesize PNA and DNA magnetic conjugates forming nanoparticle assembly based on PNA/DNA duplexes

Metabolic profiling of Pseudomonas aeruginosa demonstrates that the anti-sigma factor MucA modulates osmotic stress tolerance

The role of the glycan moiety on the structure–function relationships of PD-L1, type 1 ribosome-inactivating protein from P. dioica leaves

Formation of i-motif structure at neutral and slightly alkaline pH

Molecular genetic analysis of the orsellinic acid/F9775 gene cluster of Aspergillus nidulans

Quantitative proteome and phosphoproteome analyses of cultured cells based on SILAC labeling without requirement of serum dialysis

Back cover

Molecular BioSystems Vol - 6 Issue - 2

Molecular BioSystems Vol -5

Molecular BioSystems Vol -4

Molecular BioSystems Vol -3

Molecular BioSystems Vol -2

Protein intrinsic disorder and oligomericity in cell signaling

Content Provider	Royal Society of Chemistry (RSC)
Author	Sigalov, Alexander B.
Copyright Year	2010
Abstract	Receptor-mediated signaling plays an important role in health and disease. Recent reports have revealed that many proteins that do not adopt globular structures under native conditions, thus termed intrinsically disordered, are involved in cell signaling. Intriguingly, physiologically relevant oligomerization of intrinsically disordered proteins has been recently observed and shown to exhibit unique biophysical characteristics. On the other hand, ligand-induced or -tuned receptor oligomerization is known to be a general feature of various cell surface receptors and to play a crucial role in signal transduction. In this work, I summarize several distinct features of protein disorder that are especially important as related to signal transduction. Further, I suggest signaling-related functional connections between intrinsic disorder, receptor and protein oligomericity and hypothesize that receptor oligomerization induced or tuned upon ligand binding outside the cell is translated across the membrane into protein oligomerization inside the cell, thus providing a general platform for receptor-mediated signaling. This structures our current multidisciplinary knowledge and views of the mechanisms governing the coupling of recognition to signal transduction and cell response. Importantly, this approach not only reveals previously unrecognized striking similarities in the basic mechanistic principles of function of numerous functionally diverse and unrelated surface membrane receptors, but also suggests the similarity between therapeutic targets, thus opening new horizons for both fundamental and clinically relevant studies.
Starting Page	451
Ending Page	461
Page Count	11
File Format	HTM / HTML PDF
ISSN	1742206X
Volume Number	6
Issue Number	3
Journal	Molecular BioSystems
DOI	10.1039/b916030m
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Signal transduction Intrinsically disordered proteins Cell surface receptor Ligand Cell signaling Protein
Content Type	Text
Resource Type	Article
Subject	Molecular Biology Biotechnology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

The SCHOOL of nature: II. Protein order, disorder, and oligomericity in transmembrane signaling

Unusual biophysics of immune signaling-related intrinsically disordered proteins

On the roles of intrinsically disordered proteins and regions in cell communication and signaling

Introduction to the Thematic Minireview Series on Intrinsically Disordered Proteins

More than just tails: intrinsic disorder in histone proteins

Intrinsic disorder in S100 proteins

Differential occurrence of protein intrinsic disorder in the cytoplasmic signaling domains of cell receptors

Understanding the roles of intrinsic disorder in subunits of hemoglobin and the disease process of sickle cell anemia

Intrinsically disordered proteins play diverse roles in cell signaling

Protein intrinsic disorder and oligomericity in cell signaling

Similar Documents

The SCHOOL of nature: II. Protein order, disorder, and oligomericity in transmembrane signaling

Unusual biophysics of immune signaling-related intrinsically disordered proteins

On the roles of intrinsically disordered proteins and regions in cell communication and signaling

Introduction to the Thematic Minireview Series on Intrinsically Disordered Proteins

More than just tails: intrinsic disorder in histone proteins

Intrinsic disorder in S100 proteins

Differential occurrence of protein intrinsic disorder in the cytoplasmic signaling domains of cell receptors

Understanding the roles of intrinsic disorder in subunits of hemoglobin and the disease process of sickle cell anemia

Intrinsically disordered proteins play diverse roles in cell signaling

Protein intrinsic disorder and oligomericity in cell signaling