NDLI: Biochemical effects of venlafaxine on astrocytes as revealed by <sup>1</sup>H NMR-based metabolic profiling

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Molecular BioSystems Vol - 13 Issue - 1

Molecular BioSystems Vol -12

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Molecular BioSystems Vol -2

Biochemical effects of venlafaxine on astrocytes as revealed by ¹H NMR-based metabolic profiling

Content Provider	Royal Society of Chemistry (RSC)
Author	Liao, Li Bai, Shun-Jie Xie, Peng Sun, Lu Mao, Qiang Wang, Ling Lian, Bin Zhou, Chan-juan Liang, Zi-Hong Wu, Yu Xia, Jin-Jun Gong, Xue Wang, Xin-Fa Fang, Liang
Copyright Year	2017
Abstract	As a serotonin–norepinephrine reuptake inhibitor [SNRI], venlafaxine is one of the most commonly prescribed clinical antidepressants, with a broad range of antidepressant effects. Accumulating evidence shows that venlafaxine may target astrocytes to exert its antidepressant activity, although the underlying pharmacological mechanisms remained largely unknown. Here, we used a 1H nuclear magnetic resonance (NMR)-based metabonomics method coupled with multivariate statistical analysis to characterize the metabolic profiling of astrocytes treated with venlafaxine to explore the potential mechanism of its antidepressant effect. In total, 31 differential metabolites involved in energy, amino acid and lipid metabolism were identified. Ingenuity pathway analysis was used to identify the predicted pathways and biological functions with venlafaxine and fluoxetine. The most significantly altered network was “amino acid metabolism, cellular growth and proliferation”, with a score above 20. Certain metabolites (lysine, tyrosine, glutamate, methionine, ethanolamine, fructose-6-phosphate, and phosphorylethanolamine) are involved in and play a central role in this network. Collectively, the biological effects of venlafaxine on astrocytes provide us with the further understanding of the mechanisms by which venlafaxine treats major depressive disorder.
Starting Page	338
Ending Page	349
Page Count	12
File Format	HTM / HTML PDF
ISSN	1742206X
Volume Number	13
Issue Number	2
Journal	Molecular BioSystems
DOI	10.1039/c6mb00651e
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Antidepressant Tyrosine Metabolomics Glutamic acid Ethanolamine Phosphorylation Fluoxetine Methionine Serotonin\u2013norepinephrine reuptake inhibitor Astrocyte Metabolism Lipid Fructose Major depressive disorder Lysine Venlafaxine Nuclear magnetic resonance
Content Type	Text
Resource Type	Article
Subject	Molecular Biology Biotechnology

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Biochemical effects of venlafaxine on astrocytes as revealed by 1H NMR-based metabolic profiling

Biochemical effects of venlafaxine on astrocytes as revealed by ¹H NMR-based metabolic profiling