NDLI: A novel integrative network approach to understand the interplay between cardiovascular disease and other complex disorders

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Molecular BioSystems Vol - 7 Issue - 6

Molecular BioSystems Vol - 7 Issue - 5

Molecular BioSystems Vol - 7 Issue - 4

Molecular BioSystems Vol - 7 Issue - 3

Molecular BioSystems Vol - 7 Issue - 2

Molecular BioSystems Vol -6

Molecular BioSystems Vol -5

Molecular BioSystems Vol -4

Molecular BioSystems Vol -3

Molecular BioSystems Vol -2

A novel integrative network approach to understand the interplay between cardiovascular disease and other complex disorders

Content Provider	Royal Society of Chemistry (RSC)
Author	Rende, Deniz Kirdar, Betul Baysal, Nihat
Copyright Year	2011
Abstract	There is accumulating evidence that the proteins encoded by the genes associated with a common disorder interact with each other, participate in similar pathways and share GO terms. It has been anticipated that the functional modules in a disease related functional linkage network can be integrated with bibliomics to reveal association with other complex disorders. In this study, the cardiovascular disease functional linkage network (CFN) containing 1536 nodes and 3345 interactions was constructed using proteins encoded by 234 genes associated with the disease. Integration of CFN with bibliomics showed that 227 out of 566 functional modules are significantly associated with one or more diseases. Analysis of functional modules revealed the possible regulatory roles of SP1 and CXCL12 in the pathogenesis of cardiovascular disease (CVD) and modulation of their activities may be considered as potential therapeutic tools. The integration of CFN with bibliomics also indicated significant relations of CVD with other complex disorders. In a stratified map the members of 227 functional modules and 58 diseases in 15 disease classes were combined. In this map, leprosy, listeria monocytogenes, myasthenia, hemorrhagic diathesis and Protein S deficiency, which were not previously reported to be associated with CVD, showed significant associations. Several cancers arising from epithelial cells were also found to be linked to other diseases through hub proteins, VEGFA and PTGS2.
Starting Page	2205
Ending Page	2219
Page Count	15
File Format	HTM / HTML PDF
ISSN	1742206X
Volume Number	7
Issue Number	7
Journal	Molecular BioSystems
DOI	10.1039/c1mb05064h
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	CVD Stromal cell-derived factor 1 Protein S deficiency Gene regulatory network Leprosy Listeria monocytogenes Cardiovascular disease Bleeding diathesis CFN
Content Type	Text
Resource Type	Article
Subject	Molecular Biology Biotechnology

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Analysis of temporal gene regulation of Listeria monocytogenes revealed distinct regulatory response modes after exposure to high pressure processing

Novel treatment for congenital FXIII deficiency

Regulatory network features in Listeria monocytogenes – changing the way we talk.

Relevant bleeding diathesis due to acquired factor XIII deficiency.

Low factor V level ameliorates bleeding diathesis in patients with combined deficiency of factor V and factor VIII

Factor v (q): a bleeding diathesis associated with a qualitative platelet factor v deficiency (1984).

Bleeding diathesis and gastro-duodenal ulcers in inherited cytosolic phospholipase-A2 alpha deficiency

Phage Display-Derived Binders Able to Distinguish Listeria monocytogenes from Other Listeria Species

Factor V (Quebec): a bleeding diathesis associated with a qualitative platelet Factor V deficiency.

A novel integrative network approach to understand the interplay between cardiovascular disease and other complex disorders

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