NDLI: Alterations in urinary metabolites due to unilateral ureteral obstruction in a rodent model

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Molecular BioSystems Vol - 7 Issue - 6

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Molecular BioSystems Vol - 7 Issue - 4

Molecular BioSystems Vol - 7 Issue - 3

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Alterations in urinary metabolites due to unilateral ureteral obstruction in a rodent model

Content Provider	Royal Society of Chemistry (RSC)
Author	Trottier, Greg Karakach, Tobias K. Mataija, Diane Walter, John A. Huang, Weei Doucette, Alan MacLellan, Dawn L. Burton, Ian W. Langlois, Chantale
Copyright Year	2011
Abstract	Urinary tract obstruction (UTO) results in renal compensatory mechanisms and may progress to irrecoverable functional loss and histologic alterations. The pathophysiology of this progression is poorly understood. We identified urinary metabolite alterations in a rodent model of partial and complete UTO using 1H nuclear magnetic resonance (1H-NMR) spectroscopy. Principal component analysis (PCA) was used for classification and discovery of differentiating metabolites. UTO was associated with elevated urinary levels of alanine, succinate, dimethylglycine (DMG), creatinine, taurine, choline-like compounds, hippurate, and lactate. Decreased urinary levels of 2-oxoglutarate and citrate were noted. The patterns of alteration in partial and complete UTO were similar except that an absence of elevated urinary osmolytes (DMG and hippurate) was noted in complete UTO. This pattern of metabolite alteration indicates impaired oxidative metabolism of the mitochondria in renal proximal tubules and production of renal protective osmolytes by the medulla. Decreased production of osmolytes in complete obstruction better elucidates the pathophysiology of progression from renal compensatory mechanisms to irrecoverable changes. Further confirmation of these potential biomarkers in children with UTO is necessary.
Starting Page	2181
Ending Page	2188
Page Count	8
File Format	HTM / HTML PDF
ISSN	1742206X
Volume Number	7
Issue Number	7
Journal	Molecular BioSystems
DOI	10.1039/c1mb05080j
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Creatinine Spectroscopy Taurine Alanine Alpha-Ketoglutaric acid Metabolism Citric acid PCA Mitochondrion Succinic acid Nuclear magnetic resonance Lactic acid Rodent Dimethylglycine DMG Principal component analysis
Content Type	Text
Resource Type	Article
Subject	Molecular Biology Biotechnology

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