NDLI: Identifying the immunodeficiency gateway proteins in humans and their involvement in microRNA regulation

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Back matter

Back cover

Molecular BioSystems Vol - 7 Issue - 5

Molecular BioSystems Vol - 7 Issue - 4

Molecular BioSystems Vol - 7 Issue - 3

Molecular BioSystems Vol - 7 Issue - 2

Molecular BioSystems Vol -6

Molecular BioSystems Vol -5

Molecular BioSystems Vol -4

Molecular BioSystems Vol -3

Molecular BioSystems Vol -2

Identifying the immunodeficiency gateway proteins in humans and their involvement in microRNA regulation

Content Provider	Royal Society of Chemistry (RSC)
Author	Maulik, Ujjwal Mukhopadhyay, Anirban Bandyopadhyay, Sanghamitra Bhattacharyya, Malay
Copyright Year	2011
Abstract	Very little is known to date about the regulation protocol between transcription factors (TFs), genes and microRNAs (miRNAs) associated with diseases in various organisms. In this paper, we focus on finding the activity of miRNAs through the HIV-1 regulatory pathway in humans at the systems level. For this, we integrate and study the characteristics of the interaction information between HIV-1 and human proteins obtained from literature and prediction analysis. This information, realized in the form of a bipartite network, is subsequently mined with an exhaustive graph search technique to identify the strong significant biclusters, which are effectively the bicliques. They are unified further to form the core bipartite subnetwork. Many of the known HIV-1 associated kinase proteins (including LCK) are found in this core module. From this, the secondary significant proteins are identified by mapping these gateway proteins to the human protein–protein interaction network. Finally, these proteins are mapped onto the TF-to-miRNA and miRNA-to-gene regulatory networks derived from a couple of current studies to obtain a global view of the HIV-1 mediated TF-gene-miRNA inter-regulatory network. Interestingly, a few miRNAs participating in this pathway at the secondary level are found to have oncogenic involvement.
Starting Page	1842
Ending Page	1851
Page Count	10
File Format	HTM / HTML PDF
ISSN	1742206X
Volume Number	7
Issue Number	6
Journal	Molecular BioSystems
DOI	10.1039/c1mb05026e
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Protein\u2013protein interaction Subtypes of HIV Subnetwork Complete bipartite graph Kinase Lck Graph theory Bipartite graph Mir Core Module
Content Type	Text
Resource Type	Article
Subject	Molecular Biology Biotechnology

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Identifying the immunodeficiency gateway proteins in humans and their involvement in microRNA regulation

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