NDLI: Plasma proteomic analysis of the critical limb ischemia markers in diabetic patients with hemodialysis

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Back matter

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Molecular BioSystems Vol - 7 Issue - 5

Molecular BioSystems Vol - 7 Issue - 4

Molecular BioSystems Vol - 7 Issue - 3

Molecular BioSystems Vol - 7 Issue - 2

Molecular BioSystems Vol -6

Molecular BioSystems Vol -5

Molecular BioSystems Vol -4

Molecular BioSystems Vol -3

Molecular BioSystems Vol -2

Plasma proteomic analysis of the critical limb ischemia markers in diabetic patients with hemodialysis

Content Provider	Royal Society of Chemistry (RSC)
Author	Lu, Ying-Chieh Chen, Yi-Wen Cheng, Kuang-Chi Chou, Hsiu-Chuan Lee, Ying-Ray Hung, Peir-Haur Lyu, Ping-Chiang Chan, Hong-Lin Wu, Cheng-Tao
Copyright Year	2011
Abstract	Critical limb ischemia (CLI) is a severe obstruction of the arteries resulting from seriously decreased blood flow to the extremities, progressing to the point of pain and even skin ulcers or sores. CLI is associated with a high percentage of limb loss and mortality; however, no reliable biochemical indices are available to monitor the stages of CLI. We developed a strategy involving comparative proteomic analysis to detect CLI associated plasma biomarkers. 2D-DIGE and subsequent MALDI-TOF MS analyses provided 50 differentially expressed plasma proteins (including alkaline phosphatase and haptoglobin), between hemodialytic diabetic patients with and without CLI. Interestingly, more than half of the differentially expressed plasma proteins are associated with inflammatory responses. Our results show that CLI is strongly correlated to inflammation, indicating a strong potential for proteomics analysis in the diagnosis of CLI. To the best of our knowledge, this is the first report presenting a proteomics approach to monitor differentially expressed plasma proteins associated with CLI.
Starting Page	1990
Ending Page	1998
Page Count	9
File Format	HTM / HTML PDF
ISSN	1742206X
Volume Number	7
Issue Number	6
Journal	Molecular BioSystems
DOI	10.1039/c1mb05055a
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Alkaline phosphatase Haptoglobin Ionization Command-line interface Proteomics Inflammation Critical limb ischemia Blood plasma
Content Type	Text
Resource Type	Article
Subject	Molecular Biology Biotechnology

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