NDLI: Characterization of systemic metabolic phenotypes associated with subclinical atherosclerosis

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Back cover

Molecular BioSystems Vol -6

Molecular BioSystems Vol -5

Molecular BioSystems Vol -4

Molecular BioSystems Vol -3

Molecular BioSystems Vol -2

Characterization of systemic metabolic phenotypes associated with subclinical atherosclerosis

Content Provider	Royal Society of Chemistry (RSC)
Author	Savolainen, Markku J. Viikari, Jorma S. Ala-Korpela, Mika Lehtimäki, Terho Raitakari, Olli T. Kangas, Antti J. Juonala, Markus Kähönen, Mika Soininen, Pasi Mäkinen, Ville-Petteri Würtz, Peter Groop, Per-Henrik
Copyright Year	2011
Abstract	Detailed molecular phenotyping gives insight into disease mechanisms and can individualize medical practice for improved risk assessment and treatment. We show in an epidemiological study (n = 4309) that the multi-metabolic profiles obtained by serum NMR metabonomics inherently associate with the extent of atherosclerosis already in preclinical stages. Data-driven analysis of the spectral profiles of healthy, young adults revealed three distinct metabolic phenotypes associated with high carotid intima-media thickness (IMT), a surrogate marker of cardiovascular disease. The phenotypes were characterized by varying combinations of well-known metabolic disturbances like elevated VLDL and LDL and low HDL levels. Low IMT was also associated with distinct metabolic phenotypes with lipoprotein as well as other biochemical characteristics partly opposing those found for the high IMT phenotypes. Profiles of low-molecular-weight metabolites quantified from the experimentation were also characteristic for the metabolic phenotypes and substantiate developments toward the use of multi-metabolic risk phenotypes. The methodology can be taken as a direct extension for the routine analytics used for the risk assessment of atherosclerosis; quantification of metabolites will complement and might even replace conventional lipid measurements. Serum NMR metabonomics is therefore anticipated as a rational option for comprehensive cardiovascular risk assessment.
Starting Page	385
Ending Page	393
Page Count	9
File Format	HTM / HTML PDF
ISSN	1742206X
Volume Number	7
Issue Number	2
Journal	Molecular BioSystems
DOI	10.1039/c0mb00066c
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Low-density lipoprotein IMT Metabolomics High-density lipoprotein Very low-density lipoprotein Atherosclerosis Nuclear magnetic resonance spectroscopy Cardiovascular disease Lipoprotein Common carotid artery Lipid
Content Type	Text
Resource Type	Article
Subject	Molecular Biology Biotechnology

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Characterization of systemic metabolic phenotypes associated with subclinical atherosclerosis

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