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Molecular BioSystems Vol -6

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Molecular BioSystems Vol -2

Calorie restriction up-regulates iron and copper transport genes in Saccharomyces cerevisiae

Content Provider	Royal Society of Chemistry (RSC)
Author	Deswal, Sumit Sharma, Praveen Kumar Mittal, Nitish Roy, Nilanjan
Copyright Year	2011
Abstract	Calorie restriction (CR) is a non genetic intervention, known to confer longevity benefits across the various phyla from unicellular yeast to mammals. CR also invokes homeostatic responses similar to stress, however the sequence of molecular events leading to longevity is still illusive. In this study, we analysed the whole genome gene expression profile in response to CR, mutations mimicking CR, heat shock and H2O2 from a gene ontology perspective. Our analysis revealed that mitochondrion is a common hub in the gene expression programme under these conditions and the electron transport chain (ETC) is a major player. Consequently the genes involved in the metal ion transport were also significantly up-regulated. We confirmed the results of the in silico analysis using quantitative real time PCR which showed up-regulation of genes involved in respiration and transport of iron and copper. The promoter activity of one of the representative genes, FET3, was also found to be higher upon calorie restriction. Altogether, our results indicate that upon calorie restriction the levels of iron and copper fall in cells, which elicits a transcriptional response up-regulating the genes involved in their uptake to maintain cellular homeostasis.
Starting Page	394
Ending Page	402
Page Count	9
File Format	HTM / HTML PDF
ISSN	1742206X
Volume Number	7
Issue Number	2
Journal	Molecular BioSystems
DOI	10.1039/c0mb00084a
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Hydrogen peroxide Homeostasis Ion Gene ontology Mitochondrion Electron transport chain Polymerase chain reaction Gene Phylum Calorie restriction Cellular respiration Genome Copper Saccharomyces cerevisiae Heat shock
Content Type	Text
Resource Type	Article
Subject	Molecular Biology Biotechnology

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