NDLI: Untargeted metabolic footprinting reveals a surprising breadth of metabolite uptake and release by Synechococcus sp. PCC 7002

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Molecular BioSystems Vol - 7 Issue - 9

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Untargeted metabolic footprinting reveals a surprising breadth of metabolite uptake and release by Synechococcus sp. PCC 7002

Content Provider	Royal Society of Chemistry (RSC)
Author	Bowen, Benjamin P. Baran, Richard Northen, Trent R.
Copyright Year	2011
Abstract	Cyanobacteria are important primary producers in diverse ecosystems, yet little is known about the extent of their metabolic interactions with the environment. We have used an integrated, untargeted metabolic footprinting approach to systematically evaluate the uptake and release of metabolites between a model marine cyanobacteriumSynechococcus sp. PCC 7002 and different growth media. It was found that 47 out of 202 detected metabolites were consumed, and an additional 55 metabolites were released by the cells. Surprisingly, Synechococcus was found to uptake a great diversity of metabolites dominant in and specific to its own metabolite extract including histidine betaine (hercynine), γ-glutamyl phenylalanine and a hexosamine-based trisaccharide. This provides Synechococcus a mechanism to benefit from the lysis of part of their population (i.e. due to environmental stress or predation). Additionally, stable isotope probing was used to show that adenine and glutamate are actively metabolized following uptake. A significant turnover of glucosylglycerol, a cyanobacterial compatible solute, as opposed to a negligible turnover of the hexosamine-based trisaccharide were also observed using stable isotope probing. The untargeted metabolic footprinting approach used in this study is generally applicable to investigate metabolic interactions of microorganisms with the environment and may prove useful to construct microbial community foodwebs.
Starting Page	3200
Ending Page	3206
Page Count	7
File Format	HTM / HTML PDF
ISSN	1742206X
Volume Number	7
Issue Number	12
Journal	Molecular BioSystems
DOI	10.1039/c1mb05196b
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Glutamic acid Histidine Isotope Osmoprotectant Phenylalanine Betaine Synechococcus Cyanobacteria Lysis Adenine Metabolism Trisaccharide
Content Type	Text
Resource Type	Article
Subject	Molecular Biology Biotechnology

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cyanobacteria Synechococcus sp. strain PCC 7002

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Untargeted metabolic footprinting reveals a surprising breadth of metabolite uptake and release by Synechococcus sp. PCC 7002

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