NDLI: Completing the puzzle of aurachin biosynthesis in Stigmatella aurantiaca Sg a15

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Completing the puzzle of aurachin biosynthesis in Stigmatella aurantiaca Sg a15

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Molecular BioSystems Vol - 7 Issue - 9

Molecular BioSystems Vol - 7 Issue - 8

Molecular BioSystems Vol - 7 Issue - 7

Molecular BioSystems Vol - 7 Issue - 6

Molecular BioSystems Vol - 7 Issue - 5

Molecular BioSystems Vol - 7 Issue - 4

Molecular BioSystems Vol - 7 Issue - 3

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Completing the puzzle of aurachin biosynthesis in Stigmatella aurantiaca Sg a15

Content Provider	Royal Society of Chemistry (RSC)
Author	Müller, Rolf Li, Yanyan Sandmann, Axel Pistorius, Dominik
Copyright Year	2011
Abstract	The aurachins are a family of secondary metabolites, with the main members aurachin A, B, C, and D, produced by the myxobacteriumStigmatella aurantiacaSg a15. These isoprenoid quinoline alkaloids are classified as A-type or C-type aurachins according to the position of the farnesyl residue either at C4 or C3 of the quinoline core, respectively. Previous feeding studies revealed that the C-type aurachins are converted to A-type aurachins by late stage tailoring reactions. While the core gene cluster coding for the functionalities required for the biosynthesis of the basic structure aurachin D is known, neither of the genes encoding for the successively acting tailoring enzymes was known up to date, which was assumed to be due to a split cluster organisation. Here we describe the identification of a total of five genes, located upstream of the aurachin core cluster and at additional two loci elsewhere in the genome, encoding for the aforementioned functionalities. The generation and evaluation of respective inactivation mutants of S. aurantiacaSg a15 allowed for the first time to propose an exhaustive model for aurachin biosynthesis. One of the deduced biosynthetic transformations corresponds to a pinacol rearrangement, an unprecedented tailoring reaction in secondary metabolite biosynthesis.
Starting Page	3308
Ending Page	3315
Page Count	8
File Format	HTM / HTML PDF
ISSN	1742206X
Volume Number	7
Issue Number	12
Journal	Molecular BioSystems
DOI	10.1039/c1mb05328k
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Prenylation Terpenoid Gene Secondary metabolite Quinoline ARM Cortex-A15 Stellar classification Voltage-gated potassium channel Genome Pinacol
Content Type	Text
Resource Type	Article
Subject	Molecular Biology Biotechnology

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Completing the puzzle of aurachin biosynthesis in Stigmatella aurantiaca Sg a15

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