NDLI: Large-scale network models of IL-1 and IL-6 signalling and their hepatocellular specification

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Molecular BioSystems Vol - 7 Issue - 9

Molecular BioSystems Vol - 7 Issue - 8

Molecular BioSystems Vol - 7 Issue - 7

Molecular BioSystems Vol - 7 Issue - 6

Molecular BioSystems Vol - 7 Issue - 5

Molecular BioSystems Vol - 7 Issue - 4

Molecular BioSystems Vol - 7 Issue - 3

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Molecular BioSystems Vol -2

Large-scale network models of IL-1 and IL-6 signalling and their hepatocellular specification

Content Provider	Royal Society of Chemistry (RSC)
Author	Schaper, Fred Samaga, Regina Ryll, Anke Klamt, Steffen Alexopoulos, Leonidas G.
Copyright Year	2011
Abstract	The pro-inflammatory cytokines interleukin 1 (IL-1) and 6 (IL-6) are crucially involved in the regulation of a multitude of physiological processes, in particular coordinating the immune response upon bacterial infection and tissue injury. Both interleukins induce complex signalling cascades and trigger the production of mitogenic, pro-proliferative, anti-apoptotic, chemotactic, and pro-angiogenic factors thereby affecting the delicate balance between regenerationvs. invasive growth, tumourigenesis and metastasis. Moreover, several links to insulin resistance have been found within their associated signalling networks. Focusing on this from a systems biology perspective, we introduce comprehensive large-scale network models of IL-1 and IL-6 signalling which are based on a logical modelling approach and reflect the current biological knowledge. Theoretical network analysis enabled us to uncover general topological features and to make testable predictions on the stimulus-response behaviour of the networks. In this context, non-intuitive network-wide species dependencies as well as structures of regulatory feedback and feed-forward mechanisms could be characterised. By integrating high-throughput phosphoproteomic data from primary human hepatocytes we optimised the model structures to obtain models with high prediction accuracy for hepatocytes. Our model-based data analysis, for instance, suggested model modifications regarding (i) Akt contribution to IL-1-stimulated p38 MAPK activation and (ii) insignificant p38 MAPK activation in response to IL-6. In light of the presented results and in conjunction with the detailed model documentations, both models hold great potential for theoretical studies and practical applications.
Starting Page	3253
Ending Page	3270
Page Count	18
File Format	HTM / HTML PDF
ISSN	1742206X
Volume Number	7
Issue Number	12
Journal	Molecular BioSystems
DOI	10.1039/c1mb05261f
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Interleukin-1 family Interleukin 6 Network theory Protein kinase B Hepatocyte Systems biology P38 mitogen-activated protein kinases Mitogen-activated protein kinase Insulin resistance Metastasis Carcinogenesis Cell signaling
Content Type	Text
Resource Type	Article
Subject	Molecular Biology Biotechnology

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Large-scale network models of IL-1 and IL-6 signalling and their hepatocellular specification

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Large-scale network models of IL-1 and IL-6 signalling and their hepatocellular specification