NDLI: Cadmium toxicity in Mus musculus mice based on a metallomic study. Antagonistic interaction between Se and Cd in the bloodstream

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Metallomics Vol - 6 Issue - 2

Cadmium toxicity in Mus musculus mice based on a metallomic study. Antagonistic interaction between Se and Cd in the bloodstream

Content Provider	Royal Society of Chemistry (RSC)
Author	García-Barrera, T. Navarro, F. Gómez-Ariza, J. L. García-Sevillano, M. A.
Copyright Year	2014
Abstract	Cadmium (Cd) is an important inorganic toxicant in the environment which impacts on human health. A metallomic approach based on size-exclusion chromatography (SEC) coupled to inductively coupled plasma-mass spectrometry (ICP-MS) and multidimensional chromatography separation based on SEC coupled to affinity chromatography 2D-SEC-AF-ICP-MS have been applied to achieve a better understanding of the function, detoxification processes and regulation of metals in mice (Mus musculus) under controlled exposure to both Cd and Cd plus 77Se. Isotopic dilution analysis (IDA) was performed to quantify selenium containing proteins in mice plasma with ICP-qMS as a multielemental detector. Additionally, isotope pattern deconvolution (IPD) was applied to study the fate of enriched 77selenite in mice subjected to cadmium exposure and the effect of selenoprotein production in plasma. Moreover, the affinity of Cd for SeP in plasma of mice was corroborated using anion exchange chromatography (AEC) after AF separation and identified by organic mass spectrometry. This work illustrates the high reliability of the integrated use of inorganic and organic mass spectrometry to get a metallomic approximation, which provides a good alternative to gain deep insight into the fate of elements in exposed organisms, providing information about metal trafficking, interactions and homeostasis.
Starting Page	672
Ending Page	681
Page Count	10
File Format	HTM / HTML PDF
ISSN	17565901
Volume Number	6
Issue Number	3
Journal	Metallomics
DOI	10.1039/c3mt00350g
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Cadmium Toxicant Isotope Homeostasis Chromatography Blood plasma SEC Deconvolution Selenoprotein Affinity chromatography Anion-exchange chromatography Deep Insight House mouse Size-exclusion chromatography Automotive Electronics Council Selenium Journal of Mass Spectrometry U.S. Securities and Exchange Commission AEC
Content Type	Text
Resource Type	Article
Subject	Chemistry Medicine Metals and Alloys Biochemistry Biomaterials Biophysics

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