NDLI: Metal centers in the anaerobic microbial metabolism of CO and CO<sub>2</sub>

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Metallomics Vol - 3 Issue - 7

Metallomics Vol - 3 Issue - 6

Metallomics Vol - 3 Issue - 5

Metallomics Vol - 3 Issue - 4

Metallomics Vol - 3 Issue - 3

Metallomics Vol - 3 Issue - 2

Metallomics Vol -2

Metallomics Vol -1

Metal centers in the anaerobic microbial metabolism of CO and CO₂

Content Provider	Royal Society of Chemistry (RSC)
Author	Pierce, Elizabeth Ragsdale, Stephen W. Bender, Güneş Hill, Jeffrey A. Darty, Joseph E.
Copyright Year	2011
Abstract	Carbon dioxide and carbon monoxide are important components of the carbon cycle. Major research efforts are underway to develop better technologies to utilize the abundant greenhouse gas, CO2, for harnessing ‘green’ energy and producing biofuels. One strategy is to convert CO2 into CO, which has been valued for many years as a synthetic feedstock for major industrial processes. Living organisms are masters of CO2 and CO chemistry and, here, we review the elegant ways that metalloenzymes catalyze reactions involving these simple compounds. After describing the chemical and physical properties of CO and CO2, we shift focus to the enzymes and the metal clusters in their active sites that catalyze transformations of these two molecules. We cover how the metal centers on CO dehydrogenase catalyze the interconversion of CO and CO2 and how pyruvate oxidoreductase, which contains thiamin pyrophosphate and multiple Fe4S4 clusters, catalyzes the addition and elimination of CO2 during intermediary metabolism. We also describe how the nickel center at the active site of acetyl-CoA synthase utilizes CO to generate the central metabolite, acetyl-CoA, as part of the Wood-Ljungdahl pathway, and how CO is channelled from the CO dehydrogenase to the acetyl-CoA synthase active site. We cover how the corrinoid iron–sulfur protein interacts with acetyl-CoA synthase. This protein uses vitamin B12 and a Fe4S4 cluster to catalyze a key methyltransferase reaction involving an organometallic methyl-Co3+ intermediate. Studies of CO and CO2 enzymology are of practical significance, and offer fundamental insights into important biochemical reactions involving metallocenters that act as nucleophiles to form organometallic intermediates and catalyze C–C and C–S bond formations.
Starting Page	797
Ending Page	815
Page Count	19
File Format	HTM / HTML PDF
ISSN	17565901
Volume Number	3
Issue Number	8
Journal	Metallomics
DOI	10.1039/c1mt00042j
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Cobalamin Oxidoreductase Enzyme Chemical bond Active site Carbon dioxide Pyruvic acid Iron\u2013sulfur protein CO-methylating acetyl-CoA synthase Acetyl-CoA Metabolism Protein Carbon cycle Wood\u2013Ljungdahl pathway Organic chemistry Thiamine pyrophosphate Organometallic chemistry Greenhouse gas Nickel Carbon monoxide Catalysis
Content Type	Text
Resource Type	Article
Subject	Chemistry Medicine Metals and Alloys Biochemistry Biomaterials Biophysics

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Perchlorate-Coupled Carbon Monoxide (CO) Oxidation by Moorella glycerini, an Obligately Anaerobic, Thermophilic, Nickel-Dependent Carboxydotroph.

The metalloclusters of carbon monoxide dehydrogenase/acetyl-CoA synthase: a story in pictures

Modeling carbon monoxide dehydrogenase/acetyl-CoA synthase (CODH/ACS): a trinuclear nickel complex employing deprotonated amides and bridging thiolates

A ni-fe-cu center in a bifunctional carbon monoxide dehydrogenase/.

Crystallographic Characterization of the Carbonylated A-Cluster in Carbon Monoxide Dehydrogenase/Acetyl-CoA Synthase.

Characterization of Methyl- and Acetyl-Ni Intermediates in Acetyl CoA Synthase Formed during Anaerobic CO₂ and CO Fixation.

Origin of the Reductive Tricarboxylic Acid (rTCA) Cycle-Type CO2 Fixation: A Perspective

Metalloproteins/metalloenzymes for the synthesis of acetyl-CoA in the Wood-Ljungdahl pathway

Autocatalytic activation of acetyl-CoA synthase

Metal centers in the anaerobic microbial metabolism of CO and CO₂

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Characterization of Methyl- and Acetyl-Ni Intermediates in Acetyl CoA Synthase Formed during Anaerobic CO₂ and CO Fixation.

Metal centers in the anaerobic microbial metabolism of CO and CO₂