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Metallomics Vol - 9 Issue - 2

Metallomics Vol - 9 Issue - 1

Iron acquisition in fungal pathogens of humans

Content Provider	Royal Society of Chemistry (RSC)
Author	Kronstad, James W. Jung, Won Hee Bairwa, Gaurav
Copyright Year	2017
Abstract	The devastating infections that fungal pathogens cause in humans are underappreciated relative to viral, bacterial and parasitic diseases. In recent years, the contributions to virulence of reductive iron uptake, siderophore-mediated uptake and heme acquisition have been identified in the best studied and most life-threatening fungal pathogens: Candida albicans, Cryptococcus neoformans and Aspergillus fumigatus. In particular, exciting new work illustrates the importance of iron acquisition from heme and hemoglobin in the virulence of pathogenic yeasts. However, the challenge of establishing how these fungi gain access to hemoglobin in blood and to other sources of heme remains to be fully addressed. Recent studies are also expanding our knowledge of iron uptake in less-well studied fungal pathogens, including dimorphic fungi where new information reveals an integration of iron acquisition with morphogenesis and cell-surface properties for adhesion to host cells. Overall, the accumulating information provides opportunities to exploit iron acquisition for antifungal therapy, and new work highlights the development of specific inhibitors of siderophore biosynthesis and metal chelators for therapeutic use alone or in conjunction with existing antifungal drugs. It is clear that iron-related therapies will need to be customized for specific diseases because the emerging view is that fungal pathogens use different combinations of strategies for iron acquisition in the varied niches of vertebrate hosts.
Starting Page	215
Ending Page	227
Page Count	13
File Format	HTM / HTML PDF
ISSN	17565901
Volume Number	9
Issue Number	3
Journal	Metallomics
DOI	10.1039/c6mt00301j
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Candida albicans Morphogenesis Antifungal Cryptococcus neoformans Mycosis Siderophore Candida Virulence Vertebrate Hemoglobin Aspergillus fumigatus
Content Type	Text
Resource Type	Article
Subject	Chemistry Medicine Metals and Alloys Biochemistry Biomaterials Biophysics

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