NDLI: Effect of vanadium on calcium homeostasis, osteopontin mRNA expression, and bone microarchitecture in diabetic rats

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Metallomics Vol - 9 Issue - 2

Metallomics Vol - 9 Issue - 1

Effect of vanadium on calcium homeostasis, osteopontin mRNA expression, and bone microarchitecture in diabetic rats

Content Provider	Royal Society of Chemistry (RSC)
Author	Moreno, Laura Pietschmann, Peter Sanz-Medel, Alfredo Llopis, Juan Nebot, Elena Rodriguez-Nogales, Alba Galvez, Julio Sanchez-Gonzalez, Cristina Montes-Bayon, María Lopez-Chaves, Carlos
Copyright Year	2017
Abstract	The aim of this study was to examine whether alterations caused by diabetes in calcium homeostasis, expression of osteopontin and the microarchitecture of bone are corrected by exposure to vanadium. Four study groups were examined over a period of five weeks: control (C), diabetic (DM), diabetic treated with 1 mg V per d (DMV), and diabetic treated with 3 mg V per d (DMVH). Vanadium was supplied in drinking water as bis(maltolato)oxovanadium(IV). Calcium was measured in the food, faeces, urine, serum, kidneys, liver, muscles, and femur. Osteopontin gene expression was determined in the liver, and the bone microarchitecture was studied with the aid of micro-computed tomography. In the DM group, food intake as well as calcium absorbed and retained and liver osteopontin mRNA increased, while Ca in the serum and femur decreased, and the bone microarchitecture worsened, in comparison with the control. In the DMV group, the amount of Ca absorbed and retained was similar to DM rats. Although the Ca content in the femur increased and osteopontin mRNA decreased, there were no significant changes in the bone microarchitecture, in comparison to the DM rats. In the DMVH group, the amount of Ca absorbed and retained, and the serum and femur content were equivalent to the control. The levels of osteopontin mRNA decreased and bone mineralization improved, compared to the DM group. We conclude that treatment with 3 mg V per d of the glucose lowering agent bis(maltolato)oxovanadium(IV) causes a decrease in osteopontin mRNA, which could favour the normalization of changes in Ca homeostasis and bone microarchitecture, both at the cortical and trabecular levels, caused by diabetes.
Starting Page	258
Ending Page	267
Page Count	10
File Format	HTM / HTML PDF
ISSN	17565901
Volume Number	9
Issue Number	3
Journal	Metallomics
DOI	10.1039/c6mt00272b
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Urine Femur Calcium Liver Vanadium Homeostasis Osteopontin Glucose DMV Diabetes mellitus type 2 Microarchitecture Messenger RNA Gene DMVH Bone
Content Type	Text
Resource Type	Article
Subject	Chemistry Medicine Metals and Alloys Biochemistry Biomaterials Biophysics

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