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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Xie, Jinglin Lucy Polvi, Elizabeth J. Shekhar-Guturja, Tanvi Cowen, Leah E. |
| Description | Country affiliation: Canada Author Affiliation: Xie JL ( Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 1A8, Canada.) |
| Abstract | Fungal pathogens cause life-threatening infections in immunocompetent and immunocompromised individuals. Millions of people die each year due to fungal infections, comparable to the mortality attributable to tuberculosis or malaria. The three most prevalent fungal pathogens are Candida albicans, Cryptococcus neoformans and Aspergillus fumigatus. Fungi are eukaryotes like their human host, making it challenging to identify fungal-specific therapeutics. There is a limited repertoire of antifungals in clinical use, and drug resistance and host toxicity compromise the clinical utility. The three classes of antifungals for treatment of invasive infections are the polyenes, azoles and echinocandins. Understanding mechanisms of resistance to these antifungals has been accelerated by global and targeted approaches, which have revealed that antifungal drug resistance is a complex phenomenon involving multiple mechanisms. Development of novel strategies to block the emergence of drug resistance and render resistant pathogens responsive to antifungals will be critical to treating life-threatening fungal infections. |
| File Format | HTM / HTML |
| ISSN | 17460913 |
| Issue Number | 4 |
| Volume Number | 9 |
| e-ISSN | 17460921 |
| Journal | Future Microbiology |
| Language | English |
| Publisher | Future Medicine |
| Publisher Date | 2014-01-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | Subscribed |
| Subject Keyword | Discipline Microbiology Antifungal Agents Pharmacology Aspergillus Fumigatus Drug Effects Candida Albicans Cryptococcus Neoformans Drug Resistance, Fungal Mycoses Microbiology Isolation & Purification Azoles Echinocandins Humans Polyenes Journal Article Research Support, Non-u.s. Gov't Review |
| Content Type | Text |
| Resource Type | Article |
| Subject | Microbiology Microbiology (medical) |
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