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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Kimura, Shuichi Sasase, Tomohiko Ohta, Takeshi Sato, Eimei Matsushita, Mutsuyoshi |
| Description | Country affiliation: Japan Author Affiliation: Kimura S ( Biological/Pharmaceutical Research Laboratories, Central Pharmaceutical Research Institute, Japan Tobacco Inc., 1-1, Murasaki-cho, Takatsuki, Osaka, 569-1125, Japan. shuichi.kimura@jt.com) |
| Abstract | The Spontaneously Diabetic Torii-Lepr (fa) (SDT-fa/fa) rat is a new model of obese type 2 diabetes. The SDT-fa/fa rat shows obesity and hyperglycemia at a young age compared to the Spontaneously Diabetic Torii (SDT-+/+) rat; however, bone abnormalities in the SDT-fa/fa rat have not been investigated. The objective of the present study was to investigate the effects of obese type 2 diabetes on bone turnover, bone mass, and bone strength in the SDT-fa/fa rat. Sprague-Dawley rats were used as control animals, and SDT-+/+ rats were used as non-obese type 2 diabetic rats. Serum osteocalcin and urine deoxypyridinoline levels were decreased in SDT-fa/fa rats compared to control rats at a young age. SDT-fa/fa rats showed decreases in bone mineral density and bone mineral content of the whole tibia, and shortening of the tibia and femur compared to control and SDT-+/+ rats. Deterioration in bone geometrical properties of the femur midshaft such as cortical thickness and minimum moment of inertia, was observed in SDT-fa/fa rats compared to control and SDT-+/+ rats. Furthermore, trabecular bone volume of the distal femur was decreased in SDT-fa/fa rats compared to control rats. These negative effects on bone in SDT-fa/fa rats caused severe decreases in maximum load, stiffness, and energy absorption of the femur. In addition, serum levels of homocysteine, a candidate for bone fragility markers, were elevated in SDT-fa/fa rats compared to control and SDT-+/+ rats. In conclusion, the SDT-fa/fa rat may be a useful model to investigate bone abnormalities in obese type 2 diabetes. |
| File Format | HTM / HTML |
| ISSN | 09148779 |
| Issue Number | 3 |
| Volume Number | 30 |
| e-ISSN | 14355604 |
| Journal | Journal of Bone and Mineral Metabolism |
| Language | English |
| Publisher | Springer |
| Publisher Date | 2012-05-01 |
| Publisher Place | Japan |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Metabolism Bone Remodeling Physiology Diabetes Mellitus, Experimental Physiopathology Diabetes Mellitus, Type 2 Femur Pathology Receptors, Leptin Genetics Tibia Amino Acids Urine Animals Blood Glucose Metabolism Body Weight Bone Density Calcium Blood Homocysteine Imaging, Three-dimensional Male Organ Size Osteocalcin Radiography Rats Journal Article |
| Content Type | Text |
| Resource Type | Article |
| Subject | Orthopedics and Sports Medicine Endocrinology, Diabetes and Metabolism Endocrinology |
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