NDLI: A time-course analysis of changes in cerebral metal levels following a controlled cortical impact

Please wait, while we are loading the content...

Metallomics Vol -9

Metallomics Vol -8

Metallomics Vol - 8 Issue - 12

Metallomics Vol - 8 Issue - 9

Metallomics Vol - 8 Issue - 8

Metallomics Vol - 8 Issue - 7

Metallomics Vol - 8 Issue - 6

Metallomics Vol - 8 Issue - 5

Metallomics Vol - 8 Issue - 4

Metallomics Vol - 8 Issue - 3

Metallomics Vol - 8 Issue - 2

Front cover

Inside front cover

Contents list

The contribution of zinc to platelet behaviour during haemostasis and thrombosis

High-resolution complementary chemical imaging of bio-elements in Caenorhabditis elegans

Boron uptake, localization, and speciation in marine brown algae

Natural Hg isotopic composition of different Hg compounds in mammal tissues as a proxy for in vivo breakdown of toxic methylmercury

Inhibition of human DNA topoisomerase IB by nonmutagenic ruthenium(ii)-based compounds with antitumoral activity

A time-course analysis of changes in cerebral metal levels following a controlled cortical impact

Newport Green, a fluorescent sensor of weakly bound cellular Zn²⁺: competition with proteome for Zn²⁺

Monitoring cytosolic and ER Zn²⁺ in stimulated breast cancer cells using genetically encoded FRET sensors

An in vitro examination of selenium–cadmium antagonism using primary cultures of rainbow trout (Oncorhynchus mykiss) hepatocytes

Molecular insight into arsenic toxicity via the genome-wide deletion mutant screening of Saccharomyces cerevisiae

Differential effects of metal ions on TCDD-induced cytotoxicity and cytochrome P4501A1 gene expression in a zebrafish liver (ZFL) cell-line

New mechanistic approach of inorganic palladium toxicity: impairment in mitochondrial electron transfer

Correction: Enantiopure titanocene complexes – direct evidence for paraptosis in cancer cells

A time-course analysis of changes in cerebral metal levels following a controlled cortical impact

Content Provider	Royal Society of Chemistry (RSC)
Author	Portbury, Stuart D. Hare, Dominic J. Finkelstein, David I. Sgambelloni, Charlotte Adlard, Paul A.
Copyright Year	2016
Abstract	Traumatic brain injury (TBI) is complicated by a sudden and dramatic change in brain metal levels, including iron (Fe), copper (Cu) and zinc (Zn). Specific ‘metallo-pathological’ features of TBI include increased non-heme bound Fe and the liberation of free Zn ions, both of which may contribute to the pathogenesis of TBI. To further characterise the metal dyshomeostasis that occurs following brain trauma, we performed a quantitative time-course survey of spatial Fe, Cu and Zn distribution in mice receiving a controlled cortical impact TBI. Images of brain metal levels produced using laser ablation-inductively coupled plasma-mass spectrometry (LA-ICP-MS) in the upper quadrant of the ipsilateral hemisphere were compared to the corresponding contralateral hemisphere, together with regional areas radiating toward the center of the brain from the site of lesion. Significant regional and time point specific elevations in Fe, Zn and Cu were detected immediately and up to 28 days after TBI. The magnitude and timeframe of many of these changes suggest that TBI results in a pronounced and sustained alteration in normal metal levels within the brain. Such alterations are likely to play a role in both the short- and long-term consequences of head trauma and suggest that pharmacological modulation to normalize these metal levels may be efficacious in improving functional outcome.
Starting Page	193
Ending Page	200
Page Count	8
File Format	HTM / HTML PDF
ISSN	17565901
Volume Number	8
Issue Number	2
Journal	Metallomics
DOI	10.1039/c5mt00234f
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Cu Traumatic brain injury Time point Cerebral hemisphere Laser TBI Lesion Copper Zinc
Content Type	Text
Resource Type	Article
Subject	Chemistry Medicine Metals and Alloys Biochemistry Biomaterials Biophysics

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Age modulates the injury-induced metallomic profile in the brain

Trehalose elevates brain zinc levels following controlled cortical impact in a mouse model of traumatic brain injury

Mini Review of Controlled Cortical Impact: A Well-Suited Device for Concussion Research

1. Autonomic changes following traumatic brain injury (tbi)

The Effect of Traumatic Brain Injury on Sleep Architecture and Circadian Rhythms in Mice—A Comparison of High-Frequency Head Impact and Controlled Cortical Injury

Role of metal dyshomeostasis in Alzheimer's disease

Neuroinflammation in animal models of traumatic brain injury

A Machine Learning Approach to Investigate the Uncertainty of Tissue-Level Injury Metrics for Cerebral Contusion

Minocycline synergizes with n-acetylcysteine and improves cognition and memory following traumatic brain injury in rats (2010).

A time-course analysis of changes in cerebral metal levels following a controlled cortical impact

Similar Documents

Age modulates the injury-induced metallomic profile in the brain

Trehalose elevates brain zinc levels following controlled cortical impact in a mouse model of traumatic brain injury

Mini Review of Controlled Cortical Impact: A Well-Suited Device for Concussion Research

1. Autonomic changes following traumatic brain injury (tbi)

The Effect of Traumatic Brain Injury on Sleep Architecture and Circadian Rhythms in Mice—A Comparison of High-Frequency Head Impact and Controlled Cortical Injury

Role of metal dyshomeostasis in Alzheimer's disease

Neuroinflammation in animal models of traumatic brain injury

A Machine Learning Approach to Investigate the Uncertainty of Tissue-Level Injury Metrics for Cerebral Contusion

Minocycline synergizes with n-acetylcysteine and improves cognition and memory following traumatic brain injury in rats (2010).

A time-course analysis of changes in cerebral metal levels following a controlled cortical impact