NDLI: New mechanistic approach of inorganic palladium toxicity: impairment in mitochondrial electron transfer

Please wait, while we are loading the content...

Metallomics Vol -9

Metallomics Vol -8

Metallomics Vol - 8 Issue - 12

Metallomics Vol - 8 Issue - 9

Metallomics Vol - 8 Issue - 8

Metallomics Vol - 8 Issue - 7

Metallomics Vol - 8 Issue - 6

Metallomics Vol - 8 Issue - 5

Metallomics Vol - 8 Issue - 4

Metallomics Vol - 8 Issue - 3

Metallomics Vol - 8 Issue - 2

Front cover

Inside front cover

Contents list

The contribution of zinc to platelet behaviour during haemostasis and thrombosis

High-resolution complementary chemical imaging of bio-elements in Caenorhabditis elegans

Boron uptake, localization, and speciation in marine brown algae

Natural Hg isotopic composition of different Hg compounds in mammal tissues as a proxy for in vivo breakdown of toxic methylmercury

Inhibition of human DNA topoisomerase IB by nonmutagenic ruthenium(ii)-based compounds with antitumoral activity

A time-course analysis of changes in cerebral metal levels following a controlled cortical impact

Newport Green, a fluorescent sensor of weakly bound cellular Zn²⁺: competition with proteome for Zn²⁺

Monitoring cytosolic and ER Zn²⁺ in stimulated breast cancer cells using genetically encoded FRET sensors

An in vitro examination of selenium–cadmium antagonism using primary cultures of rainbow trout (Oncorhynchus mykiss) hepatocytes

Molecular insight into arsenic toxicity via the genome-wide deletion mutant screening of Saccharomyces cerevisiae

Differential effects of metal ions on TCDD-induced cytotoxicity and cytochrome P4501A1 gene expression in a zebrafish liver (ZFL) cell-line

New mechanistic approach of inorganic palladium toxicity: impairment in mitochondrial electron transfer

Correction: Enantiopure titanocene complexes – direct evidence for paraptosis in cancer cells

New mechanistic approach of inorganic palladium toxicity: impairment in mitochondrial electron transfer

Content Provider	Royal Society of Chemistry (RSC)
Author	Hosseini, M.-J. Jafarian, I. Farahani, S. Khodadadi, R. Mohammadi-Bardbori, A. Tagavi, S. H. Naserzadeh, P. Arghavanifard, N.
Copyright Year	2016
Abstract	Human activities have increased the levels of palladium (Pd) that are progressively accumulating in the environment. The growing evidence of Pd toxicity has become the focus of serious concern for the environment, organisms and humans, with little data on the mechanism of Pd toxicity. Recent studies have suggested that mitochondria have a key role in Pd toxicity via mitochondrial membrane potential collapse and depletion of the cellular glutathione (GSH) level. Therefore, it was decided to determine the mechanistic toxicity of Pd towards isolated mitochondria via new and reliable methods. Isolated liver and kidney mitochondria were obtained by differential ultracentrifugation and incubated with different concentrations of Pd (100–400 μM). Our results showed that Pd induced mitochondrial dysfunction via an increase in mitochondrial ROS production and membrane potential collapse, which correlated to cytochrome c release. Also, increased disturbance in oxidative phosphorylation was also shown by the increase in ADP/ATP ratio in Pd-treated mitochondria, which indicates mitochondrial dysfunction in isolated liver and kidney mitochondria. Our results suggest that Pd-induced toxicity is the result of a disruptive effect on the mitochondrial respiratory chain, increasing the chance of cell death signaling. In addition, it is supposed that kidney tissue is more susceptible to Pd exposure than liver tissue.
Starting Page	252
Ending Page	259
Page Count	8
File Format	HTM / HTML PDF
ISSN	17565901
Volume Number	8
Issue Number	2
Journal	Metallomics
DOI	10.1039/c5mt00249d
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Mitochondrion Electron transport chain Reactive oxygen species Oxidative phosphorylation Liver Membrane potential Differential centrifugation Kidney Adenosine triphosphate Glutathione
Content Type	Text
Resource Type	Article
Subject	Chemistry Medicine Metals and Alloys Biochemistry Biomaterials Biophysics

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Toxicity of vanadium on isolated rat liver mitochondria: a new mechanistic approach

Depleted uranium induces disruption of energy homeostasis and oxidative stress in isolated rat brain mitochondria

Toxicity of depleted uranium on isolated rat kidney mitochondria

Impairment of the Mitochondrial Oxidative Phosphorylation System and Oxidative Stress in Liver of Crucian Carp (Carassius auratus L.) Exposed to Microcystins (2011)

Toxicity of nano zinc oxide to mitochondria

Ciclopirox protects mitochondria from hydrogen peroxide toxicity.

Chronic myeloid leukemia stem cells display alterations in expression of genes involved in oxidative phosphorylation.

High resolution respirometry analysis of polyethylenimine-mediated mitochondrial energy crisis and cellular stress: Mitochondrial proton leak and inhibition of the electron transport system

GAPDH: the missing link between glycolysis and mitochondrial oxidative phosphorylation?

New mechanistic approach of inorganic palladium toxicity: impairment in mitochondrial electron transfer

Similar Documents

Toxicity of vanadium on isolated rat liver mitochondria: a new mechanistic approach

Depleted uranium induces disruption of energy homeostasis and oxidative stress in isolated rat brain mitochondria

Toxicity of depleted uranium on isolated rat kidney mitochondria

Impairment of the Mitochondrial Oxidative Phosphorylation System and Oxidative Stress in Liver of Crucian Carp (Carassius auratus L.) Exposed to Microcystins (2011)

Toxicity of nano zinc oxide to mitochondria

Ciclopirox protects mitochondria from hydrogen peroxide toxicity.

Chronic myeloid leukemia stem cells display alterations in expression of genes involved in oxidative phosphorylation.

High resolution respirometry analysis of polyethylenimine-mediated mitochondrial energy crisis and cellular stress: Mitochondrial proton leak and inhibition of the electron transport system

GAPDH: the missing link between glycolysis and mitochondrial oxidative phosphorylation?

New mechanistic approach of inorganic palladium toxicity: impairment in mitochondrial electron transfer