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1. Autonomic changes following traumatic brain injury (tbi)
| Content Provider | Semantic Scholar |
|---|---|
| Author | Sumner, Michael G. Hwang, Paul A. |
| Copyright Year | 2009 |
| Abstract | Objective: To explore autonomic changes associated with TBI. Rationale: Autonomic changes are associated with TBI, either as a direct result of severe TBI, a consequence of seizures, or of severe pain. Method: Three cases of dysautonomia associated with TBI, with literature review. Results: In severe TBI autonomic changes may be a direct consequence of the injury, or may cause epilepsy in severe cases. In less severe cases epilepsy can develop as a sequela of TBI-induced epileptogenesis The regions of the brain most likely to be damaged are the inferior portions of the frontal and temporal lobes and diffuse subcortical white matter in the hemispheres and the brainstem. These injuries can produce neuropsychiatric problems and neural reorganization or may trigger seizures. The seizures themselves can produce autonomic and mood changes. The treatment of choice are the mood stabilizers and the anticonvulsants. The fact that seizures and mood changes are both responsive to some of the anticonvulsants implies there is at least some commonality between these conditions. Chronic pain is very common after TBI, and may be considered a neurodegenerative disorder which may further trigger seizures, but the exact mechanism is unknown. Autonomic dysfunction is common with chronic pain. Conclusion: Autonomic changes are common after TBI and these changes are related to seizure-like phenomena. Chronic pain is common after TBI. It is speculated that chronic pain produces seizures which produce further autonomic changes, but this process needs to be investigated further. The validity of this proposed hypothesis requires further elucidation. |
| File Format | PDF HTM / HTML |
| DOI | 10.1016/j.clinph.2009.05.021 |
| Volume Number | 120 |
| Alternate Webpage(s) | https://api.elsevier.com/content/article/pii/S1388245709003733 |
| Alternate Webpage(s) | https://www.sciencedirect.com/science/article/pii/S1388245709003733?dgcid=api_sd_search-api-endpoint |
| Alternate Webpage(s) | https://doi.org/10.1016/j.clinph.2009.05.021 |
| Journal | Clinical Neurophysiology |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
