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Metallomics Vol - 7 Issue - 7

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Metallomics Vol - 7 Issue - 5

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Metallomics Vol - 7 Issue - 3

Metallomics Vol - 7 Issue - 2

Is interaction of amyloid β-peptides with metals involved in cognitive activity?

Content Provider	Royal Society of Chemistry (RSC)
Author	Takeda, Atsushi Tamano, Haruna
Copyright Year	2015
Abstract	Metal ions, i.e., Zn2+ and Cu2+, are released from neuron terminals in the hippocampus, which plays important roles in spatial and declarative memory, and may serve as a signal factor. Synaptic homeostasis of metal ions is critical for cognitive activity in the hippocampus. Amyloid-β (Aβ) is a causative candidate for the pathogenesis of Alzheimer's disease (AD) and Aβ-induced synapse dysfunction is easy to emerge along with normal aging and leads to the cognitive decline and memory loss in the pre-dementia stage of AD. Because Aβ interacts with Zn2+ and Cu2+, it is likely that these metal ions are involved in the Aβ-induced modification of the synaptic function. There is evidence to indicate that the inhibition of the interaction of Aβ with Zn2+ and Cu2+ may ameliorate the pathophysiology of AD. Interaction of extracellular Zn2+ with Aβ in the hippocampus is involved in transiently Aβ-induced cognition deficits, while the interaction of extracellular Cu2+ reduces bioavailability of intracellular Cu2+, followed by an increase in oxidative stress, which may lead to cognitive deficits. It is likely that Zn2+ and Cu2+ play as a key-mediating factor in pathophysiology of the synaptic dysfunction in which Aβ is involved. Based on the idea that understating Aβ-induced changes in synaptic plasticity is important to prevent AD, the present paper summarizes the interaction of Aβ with metal ions in cognition.
Starting Page	1205
Ending Page	1212
Page Count	8
File Format	HTM / HTML PDF
ISSN	17565901
Volume Number	7
Issue Number	8
Journal	Metallomics
DOI	10.1039/c5mt00076a
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Oxidative stress Synapse Neuron Memory Synaptic plasticity Homeostasis Explicit memory Bioavailability Hippocampus
Content Type	Text
Resource Type	Article
Subject	Chemistry Medicine Metals and Alloys Biochemistry Biomaterials Biophysics

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