NDLI: Dissolvable membranes as sensing elements for microfluidics based biological/chemical sensors

Content Provider	Royal Society of Chemistry (RSC)
Author	Beebe, David J. Jiang, Hongrui Sridharamurthy, Sudheer S. Agarwal, Abhishek K.
Copyright Year	2006
Abstract	We demonstrate a chemical and biological sensing mechanism in microfluidics that transduces chemical and biological signals to electrical signals with large intrinsic amplification without need for complex electronics. The sensing mechanism involves a dissolvable membrane separating a liquid sample chamber from an interdigitated electrode. Dissolution of the membrane (here, a disulfide cross-linked poly(acrylamide) hydrogel) in the presence of a specific target (here, a reducing agent—dithiothreitol) allows the target solution to flow into contact with the electrode. The liquid movement displaces the air dielectric with a liquid, leading to a change (open circuit to ∼1 kΩ) in the resistance between the electrodes. Thus, a biochemical event is transduced into an electrical signal via fluid movement. The concentration of the target is estimated by monitoring the difference in dissolution times of two juxtaposed sensing membranes having different dissolution characteristics. No dc power is consumed by the sensor until detection of the target. A range of targets could be sensed by defining membranes specific to the target. This sensing mechanism might find applications in sensing targets such as toxins, which exhibit enzymatic activity.
Starting Page	840
Ending Page	842
Page Count	3
File Format	HTM / HTML PDF
ISSN	14730197
Volume Number	6
Issue Number	7
Journal	Lab on a Chip
DOI	10.1039/b607066c
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Subscribed
Subject Keyword	Acrylamide Electrode Disulfide Dielectric Microfluidics Gel
Content Type	Text
Resource Type	Article
Subject	Chemistry Nanoscience and Nanotechnology Biochemistry Bioengineering Biomedical Engineering

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