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Contents

Inside front cover

Research Highlights ( Lab on a Chip Vol - 6 Issue - 6 )

Electrostatic induction of the electric field into free-flow electrophoresis devices

Electrokinetic flow control in microfluidic chips using a field-effect transistor

Rapid heterogeneous liver-cell on-chip patterning via the enhanced field-induced dielectrophoresis trap

An optically driven pump for microfluidics

The liquid–liquid diffusive extraction of hydrocarbons from a North Sea oil using a microfluidic format

Electronic drop sensing in microfluidic devices: automated operation of a nanoliter viscometer

Microfluidics assisted synthesis of well-defined spherical polymeric microcapsules and their utilization as potential encapsulants

Timing controllable electrofusion device for aqueous droplet-based microreactors

A microfluidic multi-injector for gradient generation

Deposition of PEG onto PMMA microchannel surface to minimize nonspecific adsorption

Centrifugal extraction of plasma from whole blood on a rotating disk

Delivery of nanogram payloads using magnetic porous silicon microcarriers

Characterisation of spatial and temporal changes in pH gradients in microfluidic channels using optically trapped fluorescent sensors

Disposable integrated microfluidic biochip for blood typing by plastic microinjection moulding

Design, fabrication and characterization of monolithic embedded parylene microchannels in silicon substrate

Off-line form of the Michaelis–Menten equation for studying the reaction kinetics in a polymer microchip integrated with enzyme microreactor

Electric cell-substrate impedance sensing with screen printed electrode structures

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Lab on a Chip Vol - 6 Issue - 5

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Lab on a Chip Vol - 6 Issue - 2

Disposable integrated microfluidic biochip for blood typing by plastic microinjection moulding

Content Provider	Royal Society of Chemistry (RSC)
Author	Lee, Jae Y. Lee, Se Hwan Kim, Dong Sung Ahn, Chong H. Kwon, Tai Hun
Copyright Year	2006
Abstract	Blood typing is the most important test for both transfusion recipients and blood donors. In this paper, a low cost disposable blood typing integrated microfluidic biochip has been designed, fabricated and characterized. In the biochip, flow splitting microchannels, chaotic micromixers, reaction microchambers and detection microfilters are fully integrated. The loaded sample blood can be divided by 2 or 4 equal volumes through the flow splitting microchannel so that one can perform 2 or 4 blood agglutination tests in parallel. For the purpose of obtaining efficient reaction of agglutinogens on red blood cells (RBCs) and agglutinins in serum, we incorporated a serpentine laminating micromixer into the biochip, which combines two chaotic mixing mechanisms of splitting/recombination and chaotic advection. Relatively large area reaction microchambers were also introduced for the sake of keeping the mixture of the sample blood and serum during the reaction time before filtering. The gradually decreasing multi-step detection microfilters were designed in order to effectively filter the reacted agglutinated RBCs, which show the corresponding blood group. To achieve the cost-effectiveness of the microfluidic biochip for disposability, the biochip was realized by the microinjection moulding of COC (cyclic olefin copolymer) and thermal bonding of two injection moulded COC substrates in mass production with a total fabrication time of less than 20 min. Mould inserts of the biochip for the microinjection moulding were fabricated by SU-8 photolithography and the subsequent nickel electroplating process. Human blood groups of A, B and AB have been successfully determined with the naked eye, with 3 µl of the whole sample bloods, by means of the fabricated biochip within 3 min.
Starting Page	794
Ending Page	802
Page Count	9
File Format	HTM / HTML PDF
ISSN	14730197
Volume Number	6
Issue Number	6
Journal	Lab on a Chip
DOI	10.1039/b516495h
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Nickel electroplating Carrier generation and recombination Disposability Blood transfusion Cyclic olefin copolymer SU-8 photoresist Microchannel (microtechnology) Hemagglutination Advection Microinjection COC Mould Micromixer Photolithography Chaotic mixing
Content Type	Text
Resource Type	Article
Subject	Chemistry Nanoscience and Nanotechnology Biochemistry Bioengineering Biomedical Engineering

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3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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Investigation of Solvent-Assisted In-Mold Bonding of Cyclic Olefin Copolymer (COC) Microfluidic Chips

Protein Microarray on Cyclic Olefin Copolymer (coc) for Disposable Protein Lab-on-a-chip

Kmpr photoresist for fabrication of thick microstructures.

A cell-laden microfluidic hydrogel

Micromachining Microchannels on Cyclic Olefin Copolymer (COC) Substrates with the Taguchi Method

Tacky cyclic olefin copolymer: a biocompatible bonding technique for the fabrication of microfluidic channels in COC.

Analysis of Passive Mixing in a Serpentine Microchannel with Sinusoidal Side Walls

Design and Manufacturing of a Disposable, Cyclo-Olefin Copolymer, Microfluidic Biosensor

Disposable Optical Stretcher Fabricated by Microinjection Moulding

Disposable integrated microfluidic biochip for blood typing by plastic microinjection moulding

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Investigation of Solvent-Assisted In-Mold Bonding of Cyclic Olefin Copolymer (COC) Microfluidic Chips

Protein Microarray on Cyclic Olefin Copolymer (coc) for Disposable Protein Lab-on-a-chip

Kmpr photoresist for fabrication of thick microstructures.

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Micromachining Microchannels on Cyclic Olefin Copolymer (COC) Substrates with the Taguchi Method

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Disposable integrated microfluidic biochip for blood typing by plastic microinjection moulding