NDLI: Motor-assisted chip-in-a-tube (MACT): a new 2- and 3-dimensional centrifugal microfluidic platform for biomedical applications

Content Provider	Royal Society of Chemistry (RSC)
Author	Loo, Jacky Fong-Chuen Kwok, Ho-Chin Ho, Ho-Pui Wang, Yuye Hui, Mamie Kong, Siu-Kai Zhang, Xuping Leung, Czarina Chi-Hung Wang, Guanghui Tang, Minghui
Copyright Year	2017
Abstract	Currently, centrifuge apparatus is primarily an end-point sample processing piece of equipment. The lack of real-time active control has imposed an inherent limitation such that many delicate sample processing steps requiring immediate and accurate intervention have never been possible. We report herein a motor-assisted chip-in-a-tube (MACT) platform in which a microfluidic chip placed inside a common centrifuge canister can be rotated through wireless control in order to manipulate the centrifugal force vector in a 3-dimensional (3D) manner. As a demonstration experiment, we have used our MACT prototype to perform the operation for two common biomedical procedures, namely human blood plasma separation and E. coli plasmid DNA extraction. This simple, yet highly effective and versatile approach may serve as a generic one-for-all platform for a wide range of common laboratory experiments and bioassay applications.
Starting Page	474
Ending Page	483
Page Count	10
File Format	HTM / HTML PDF
ISSN	14730197
Volume Number	17
Issue Number	3
Journal	Lab on a Chip
DOI	10.1039/c6lc01169a
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Plasmid DNA extraction Bioassay Euclidean vector Escherichia coli Centrifugal force Three-dimensional space Blood plasma
Content Type	Text
Resource Type	Article
Subject	Chemistry Nanoscience and Nanotechnology Biochemistry Bioengineering Biomedical Engineering

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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Motor-assisted chip-in-a-tube (MACT): a new 2- and 3-dimensional centrifugal microfluidic platform for biomedical applications