NDLI: 3D microvascular model recapitulates the diffuse large B-cell lymphoma tumor microenvironment in vitro

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Lab on a Chip Vol -17

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Inside front cover

Contents list

Thermoplastic nanofluidic devices for biomedical applications

Miniaturized devices for point of care molecular detection of HIV

Acoustic actuation of bioinspired microswimmers

Magnetic separation of microparticles by shape

3D microvascular model recapitulates the diffuse large B-cell lymphoma tumor microenvironment in vitro

Separation and dual detection of prostate cancer cells and protein biomarkers using a microchip device

Liquid-capped encoded microcapsules for multiplex assays

Surface acoustic wave enabled pipette on a chip

A 3D neurovascular microfluidic model consisting of neurons, astrocytes and cerebral endothelial cells as a blood–brain barrier

Pinch-off dynamics and dripping-onto-substrate (DoS) rheometry of complex fluids

Motor-assisted chip-in-a-tube (MACT): a new 2- and 3-dimensional centrifugal microfluidic platform for biomedical applications

Automated 3D-printed unibody immunoarray for chemiluminescence detection of cancer biomarker proteins

High efficiency hydrodynamic bacterial electrotransformation

Crossed flow microfluidics for high throughput screening of bioactive chemical–cell interactions

A vascularized and perfused organ-on-a-chip platform for large-scale drug screening applications

Visual detection of multiple genetically modified organisms in a capillary array

Chromatin immunoprecipitation in microfluidic droplets: towards fast and cheap analyses

Versatile tissue lasers based on high-Q Fabry–Pérot microcavities

Towards encoded particles for highly multiplexed colorimetric point of care autoantibody detection

Control and automation of multilayered integrated microfluidic device fabrication

Correction: Double-emulsion drops with ultra-thin shells for capsule templates

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Lab on a Chip Vol - 17 Issue - 2

Lab on a Chip Vol - 17 Issue - 1

3D microvascular model recapitulates the diffuse large B-cell lymphoma tumor microenvironment in vitro

Content Provider	Royal Society of Chemistry (RSC)
Author	Qiu, Yongzhi Mejias, Joscelyn C. Santiago-Miranda, Adriana N. Neelapu, Sattva S. Lam, Wilbur A. Mannino, Robert G. Roy, Krishnendu Pradhan, Pallab
Copyright Year	2017
Abstract	Diffuse large B-cell lymphoma (DLBCL) is an aggressive cancer that affects ∼22 000 people in the United States yearly. Understanding the complex cellular interactions of the tumor microenvironment is critical to the success and development of DLBCL treatment strategies. In vitro platforms that successfully model the complex tumor microenvironment without introducing the variability of in vivo systems are vital for understanding these interactions. To date, no such in vitro model exists that can accurately recapitulate the interactions that occur between immune cells, cancer cells, and endothelial cells in the tumor microenvironment of DLBCL. To that end, we developed a lymphoma-on-chip model consisting of a hydrogel based tumor model traversed by a vascularized, perfusable, round microchannel that successfully recapitulates key complexities and interactions of the in vivo tumor microenvironment in vitro. We have shown that the perfusion capabilities of this technique allow us to study targeted treatment strategies, as well as to model the diffusion of infused reagents spatiotemporally. Furthermore, this model employs a novel fabrication technique that utilizes common laboratory materials, and allows for the microfabrication of multiplex microvascular environments without the need for advanced microfabrication facilities. Through our facile microfabrication process, we are able to achieve micro vessels within a tumor model that are highly reliable and precise over the length of the vessel. Overall, we have developed a tool that enables researchers from many diverse disciplines to study previously inaccessible aspects of the DLBCL tumor microenvironment, with profound implications for drug delivery and design.
Starting Page	407
Ending Page	414
Page Count	8
File Format	HTM / HTML PDF
ISSN	14730197
Volume Number	17
Issue Number	3
Journal	Lab on a Chip
DOI	10.1039/c6lc01204c
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	DLBCL United States Perfusion Microfabrication Drug delivery Diffusion Diffuse large B-cell lymphoma Cancer Endothelium Gel
Content Type	Text
Resource Type	Article
Subject	Chemistry Nanoscience and Nanotechnology Biochemistry Bioengineering Biomedical Engineering

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

The biology of the tumor microenvironment in DLBCL: Targeting the "don't eat me" signal.

Primary cutaneous Epstein-Barr virus-positive diffuse large B-cell lymphoma (DLBCL) in a patient taking fingolimod

DLBCL Diffuse large B-cell lymphoma (2014)

Oncogenic Mutations and Tumor Microenvironment Alterations of Older Patients With Diffuse Large B-Cell Lymphoma

A glycolysis-related gene signatures in diffuse large B-Cell lymphoma predicts prognosis and tumor immune microenvironment

Scouting out the neighborhood in AIDS-related lymphoma

Identification of prognostic tumor markers in HIV+ diffuse large B-cell lymphoma (DLBCL).

Diffuse Large B-Cell Breast Lymphoma: A Case Series

A bone-based 3D scaffold as an in-vitro model of microenvironment–DLBCL lymphoma cell interaction

3D microvascular model recapitulates the diffuse large B-cell lymphoma tumor microenvironment in vitro

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The biology of the tumor microenvironment in DLBCL: Targeting the "don't eat me" signal.

Primary cutaneous Epstein-Barr virus-positive diffuse large B-cell lymphoma (DLBCL) in a patient taking fingolimod

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Oncogenic Mutations and Tumor Microenvironment Alterations of Older Patients With Diffuse Large B-Cell Lymphoma

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