NDLI: Shape engineering boosts antibacterial activity of chitosan coated mesoporous silica nanoparticle doped with silver: a mechanistic investigation

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Journal of Materials Chemistry B Vol - 4 Issue - 9

Journal of Materials Chemistry B Vol - 4 Issue - 8

Journal of Materials Chemistry B Vol - 4 Issue - 7

Journal of Materials Chemistry B Vol - 4 Issue - 6

Journal of Materials Chemistry B Vol - 4 Issue - 5

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Journal of Materials Chemistry B Vol -1

Shape engineering boosts antibacterial activity of chitosan coated mesoporous silica nanoparticle doped with silver: a mechanistic investigation

Content Provider	Royal Society of Chemistry (RSC)
Author	Odén, M. Sarwar, S. Björk, E. M. Chakraborti, S. Desai, D. Rosenholm, J. M. Karaman, D. Şen Chakrabarti, P.
Copyright Year	2016
Abstract	In this study, mesoporous silica nanoparticles (MSPs) of different size and shape were developed, and their surface coatings were utilized to study their differential effects in enhancing antibacterial activity. In brief, MSPs with three different aspect ratios (1, 2 and 4) were prepared, doped with silver ions and finally coated with the polymer chitosan. Both Gram-positive and Gram-negative bacteria were treated with the MSPs. Results indicate that silver ion doped and chitosan coated MSPs with the aspect ratio of 4 (Cht/MSP4:Ag+) have the highest antimicrobial activity among the prepared series. Further studies revealed that Cht/MSP4:Ag+ was most effective against Escherichia coli (E.coli) and least effective against Vibrio cholerae (V. cholerae). To investigate the detailed inhibition mechanism of the MSPs, the interaction of the nanoparticles with E.coli membranes and its intracellular DNA was assessed using various spectroscopic and imaging-based techniques. Furthermore, to increase the efficiency of the MSPs, a combinatorial antibacterial strategy was also explored, where nanoparticles, in combination with kanamycin (antibiotic), were used against Vibrio Cholerae (V. cholerae). Toxicity screening of these on MSPs was conducted on Caco-2 cells, and the results show that the dose used for antibacterial screening is below the limit of the toxicity threshold. Our findings show that both shape and surface engineering contribute positively towards killing bacteria, and the newly developed silver ion-doped and chitosan-coated MSPs have good potential as antimicrobial nanomaterials.
Starting Page	3292
Ending Page	3304
Page Count	13
File Format	HTM / HTML PDF
ISSN	2050750X
Volume Number	4
Issue Number	19
Journal	Journal of Materials Chemistry B
DOI	10.1039/c5tb02526e
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Vibrio Vibrio Cholerae Mesoporous silica Polymer Chitosan Gram-positive bacteria Gram-negative bacteria Ion Aspect ratio Antimicrobial Escherichia coli DNA Combinatorics Kanamycin A Antibiotics Caco-2 Bacteria Nanomaterials
Content Type	Text
Resource Type	Article
Subject	Chemistry Medicine Materials Science Biomedical Engineering

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