NDLI: The influence of selected NSAIDs on volume phase transition in poly(2-(2-methoxyethoxy)ethyl methacrylate) hydrogels

Content Provider	Royal Society of Chemistry (RSC)
Author	Adamus, Agnieszka Koynov, Kaloian Piechocki, Krzysztof Wach, Radosław A. Kozanecki, Marcin Olejniczak, Magdalena N.
Copyright Year	2016
Abstract	Hydrogels exhibiting Volume Phase Transition (VPT) are considered as useful biomaterials for the preparation of various drug delivery systems. Such hydrogels are commonly based on thermo-responsive polymers, such as poly(2-(2-methoxyethoxy)ethyl methacrylate) (PMEO2MA), that have lower critical solution temperature (LCST) in aqueous solutions. In this work, PMEO2MA hydrogels were used as model systems to study the influence of encapsulated drugs, such as ibuprofen and salicylate sodium salts, on the temperature and dynamics of the VPT. Both thermo-optical analysis and differential scanning calorimetry have shown that the VPT becomes broader and shifts towards higher temperatures with increasing drug concentration. Three regimes of VPT in PMEO2MA gels were distinguished. The first two, related to the breaking of the strong water–polymer interactions and to the network collapse, slow down with increasing drug concentration. The last regime, corresponding to the slow diffusion of a residual solution from a collapsing network, becomes visible only for systems with high content of drug. Raman spectroscopy studies show that the observed effect is not connected to direct interactions between polymers and drugs. This suggests that the drug molecules are able to stabilise water–polymer interactions in thermo-responsive hydrogels. Consequently, they are able to modulate VPT and have a significant influence on the delivery process.
Starting Page	1528
Ending Page	1534
Page Count	7
File Format	HTM / HTML PDF
ISSN	2050750X
Volume Number	4
Issue Number	8
Journal	Journal of Materials Chemistry B
DOI	10.1039/c5tb02217g
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Subscribed
Subject Keyword	Raman Phase transition Biomaterial Drug delivery Ibuprofen Sodium Differential scanning calorimetry Diffusion Raman spectroscopy
Content Type	Text
Resource Type	Article
Subject	Chemistry Medicine Materials Science Biomedical Engineering

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