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Polycaprolactone fibers with self-assembled peptide micro/nanotubes: a practical route towards enhanced mechanical strength and drug delivery applications

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Journal of Materials Chemistry B Vol - 4 Issue - 7

Journal of Materials Chemistry B Vol - 4 Issue - 6

Journal of Materials Chemistry B Vol - 4 Issue - 5

Journal of Materials Chemistry B Vol -3

Journal of Materials Chemistry B Vol -2

Journal of Materials Chemistry B Vol -1

Polycaprolactone fibers with self-assembled peptide micro/nanotubes: a practical route towards enhanced mechanical strength and drug delivery applications

Content Provider	Royal Society of Chemistry (RSC)
Author	Silva, E. R. da Liberato, M. S. Guha, S. Araujo, D. R. de Alves, W. A. Kogikoski, S.
Copyright Year	2016
Abstract	Peptide-based scaffolds are a frontier research area in materials science with widespread impact in biomedical engineering. In this paper, we describe a hybrid material formulated through the conjugation of electrospun polycaprolactone (PCL) fibers and micro/nanotubes of L,L-diphenylalanine (FF-MNTs). Morphology and crystallinity of the composite matrices are investigated using a wide range of analytical techniques including electron microscopy, thermal analyses, X-ray diffraction and micro-tomography. Peptide assemblies are found to produce deep modifications on the microstructure of PCL fibers, impacting average diameters, crystallinity degree and porous size in the polymer network. These changes are correlated with mechanical properties of the resulting scaffolds, whose strength is found to exhibit a brittle-to-ductile transition upon increasing the amount of FF-MNTs and lead to enhanced Young's moduli of polymer fibers. The PCL/FF-MNTs composites were tested for the drug delivery application of a lipophilic drug, benzocaine. In vitro permeation studies have shown that these polymer/peptide hybrids are able to produce a steady release of benzocaine over periods of up to ∼13 hours, much higher than commercially available gel formulations. Enzymatic tests have shown a significant increment in biodegradation rates in PCL/FF-MNTs hybrids containing higher peptide amounts, which exhibited almost 100% weight loss against only 10% found in pure PCL. Our findings indicate that using PCL/FF-MNTs materials is a simple route towards achieving enhanced mechanical strength of PCL networks that have the ability to promote controlled drug delivery from a completely biodegradable matrix.
Starting Page	1405
Ending Page	1413
Page Count	9
File Format	HTM / HTML PDF
ISSN	2050750X
Volume Number	4
Issue Number	8
Journal	Journal of Materials Chemistry B
DOI	10.1039/c5tb02240a
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Subscribed
Subject Keyword	Materials science Biomedical engineering Polycaprolactone Transmission electron microscopy Polymer Drug delivery Lipophilicity Benzocaine Peptide 13 Hours (book) Biodegradation Drug prohibition law Composite material
Content Type	Text
Resource Type	Article
Subject	Chemistry Medicine Materials Science Biomedical Engineering

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