NDLI: Synthesis, characterization and biological evaluation of a new photoactive hydrogel against Gram-positive and Gram-negative bacteria

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Back cover

Journal of Materials Chemistry B Vol - 4 Issue - 7

Journal of Materials Chemistry B Vol - 4 Issue - 6

Journal of Materials Chemistry B Vol - 4 Issue - 5

Journal of Materials Chemistry B Vol -3

Journal of Materials Chemistry B Vol -2

Journal of Materials Chemistry B Vol -1

Synthesis, characterization and biological evaluation of a new photoactive hydrogel against Gram-positive and Gram-negative bacteria

Content Provider	Royal Society of Chemistry (RSC)
Author	Wainwright, Mark Boyle, Ross W. Spagnul, Cinzia Kamil, Zeeniya Greenman, John
Copyright Year	2016
Abstract	In 2013, the World Health Organization reported that 884 million people lack access to clean potable water. Photodynamic antimicrobial chemotherapy (PACT) is a very promising alternative to conventional antibiotics for the efficient inactivation of pathogenic microorganisms. We report the synthesis, characterization and antibacterial activity of a polyacrylamide-based hydrogel (7), with a new photoactive phenothiazinium compound (6) immobilized on it, to be used as a novel water-sterilizing device. The hydrogel was characterized by IR and scanning electron microscopy and incorporation of the dye confirmed by UV-visible spectroscopy. Antibacterial tests using the recombinant bioluminescent Gram-positive Staphylococcus aureus RN4220 and Gram-negative Escherichia coli DH5α were performed to assess the ability of the hydrogel to inactivate bacterial strains in solution. The hydrogel is characterized by a non-ordered microporous structure and is able to generate reactive oxygen species. The hydrogel is able to inactivate planktonic cells of the S. aureus and E. coli (3.3 log and 2.3 log killing, respectively) after 25 min of irradiation with white light at 14.5 mW cm−2. The contact surface does not influence the kill rates while the killing rate increased by increasing the total amount of the hydrogel (0.27 log drop to 1.65 log drop with 0.5 mg cm−3 to 2.5 mg cm−3 of total amount of dye). The hydrogel was found to be active for four cycles, suggesting the possibility of reuse and it was shown to be active against both Gram-positive and Gram-negative species with no leaching of the active molecule.
Starting Page	1499
Ending Page	1509
Page Count	11
File Format	HTM / HTML PDF
ISSN	2050750X
Volume Number	4
Issue Number	8
Journal	Journal of Materials Chemistry B
DOI	10.1039/c5tb02569a
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Subscribed
Subject Keyword	World Health Organization Antimicrobial Chemotherapy Gel Scanning electron microscope Staining Ultraviolet\u2013visible spectroscopy Bioluminescence Gram-positive bacteria Aureus Gram-negative bacteria Escherichia coli Reactive oxygen species
Content Type	Text
Resource Type	Article
Subject	Chemistry Medicine Materials Science Biomedical Engineering

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4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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