Please wait, while we are loading the content...
Please wait, while we are loading the content...
| Content Provider | Royal Society of Chemistry (RSC) |
|---|---|
| Author | Zeng, Jin Liu, Peng Yang, Huiying Du, Pengcheng |
| Copyright Year | 2013 |
| Abstract | A facile and effective approach was developed to fabricate folic acid-conjugated temperature-sensitive hollow microspheres with movable pH-responsive cores for a targeted drug delivery system (DDS) via two-stage distillation precipitation polymerization. The yolk/shell structure of the microspheres obtained was revealed by transmission electron microscopy (TEM). Their monodisperse poly(methacrylic acid-co-ethyleneglycol dimethacrylate) (P(MAA-co-EGDMA)) microgel cores expressed obvious pH stimulus-response characteristics from Dynamical Light Scattering (DLS) analysis, and their functional crosslinked poly(N-isopropylacrylamide) (PNIPAM) shells exhibited obvious temperature stimulus-responses with diameters related to the degree of crosslinking and monomer proportion. Their independent temperature and pH dual-stimulus controlled release of drug molecules (using a model anti-cancer drug, doxorubicin (DOX)) was also investigated in simulated human body fluids. Meanwhile, the FA conjugated targeting temperature-sensitive hollow microspheres with pH-responsive cores expressed excellent biocompatibility on HepG2 cells. Consequently, the precise molecular targeting properties produced by the surface folic acid groups and the independent temperature and pH dual-stimulus responsive characteristics from the unique yolk/shell structure offers promise for cancer treatment. |
| Starting Page | 5298 |
| Ending Page | 5308 |
| Page Count | 11 |
| File Format | HTM / HTML PDF |
| ISSN | 2050750X |
| Volume Number | 1 |
| Issue Number | 39 |
| Journal | Journal of Materials Chemistry B |
| DOI | 10.1039/c3tb20975j |
| Language | English |
| Publisher | Royal Society of Chemistry |
| Access Restriction | Open |
| Subject Keyword | FA Drug delivery Distillation Precipitation polymerization Yolk Thin-shell structure Transmission electron microscopy Dispersity PH Dynamic light scattering Poly(N-isopropylacrylamide) Monomer Doxorubicin Biocompatibility Cancer |
| Content Type | Text |
| Resource Type | Article |
| Subject | Chemistry Medicine Materials Science Biomedical Engineering |
National Digital Library of India (NDLI) is a virtual repository of learning resources which is not just a repository with search/browse facilities but provides a host of services for the learner community. It is sponsored and mentored by Ministry of Education, Government of India, through its National Mission on Education through Information and Communication Technology (NMEICT). Filtered and federated searching is employed to facilitate focused searching so that learners can find the right resource with least effort and in minimum time. NDLI provides user group-specific services such as Examination Preparatory for School and College students and job aspirants. Services for Researchers and general learners are also provided. NDLI is designed to hold content of any language and provides interface support for 10 most widely used Indian languages. It is built to provide support for all academic levels including researchers and life-long learners, all disciplines, all popular forms of access devices and differently-abled learners. It is designed to enable people to learn and prepare from best practices from all over the world and to facilitate researchers to perform inter-linked exploration from multiple sources. It is developed, operated and maintained from Indian Institute of Technology Kharagpur.
Learn more about this project from here.
NDLI is a conglomeration of freely available or institutionally contributed or donated or publisher managed contents. Almost all these contents are hosted and accessed from respective sources. The responsibility for authenticity, relevance, completeness, accuracy, reliability and suitability of these contents rests with the respective organization and NDLI has no responsibility or liability for these. Every effort is made to keep the NDLI portal up and running smoothly unless there are some unavoidable technical issues.
Ministry of Education, through its National Mission on Education through Information and Communication Technology (NMEICT), has sponsored and funded the National Digital Library of India (NDLI) project.
| Sl. | Authority | Responsibilities | Communication Details |
|---|---|---|---|
| 1 | Ministry of Education (GoI), Department of Higher Education |
Sanctioning Authority | https://www.education.gov.in/ict-initiatives |
| 2 | Indian Institute of Technology Kharagpur | Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project | https://www.iitkgp.ac.in |
| 3 | National Digital Library of India Office, Indian Institute of Technology Kharagpur | The administrative and infrastructural headquarters of the project | Dr. B. Sutradhar bsutra@ndl.gov.in |
| 4 | Project PI / Joint PI | Principal Investigator and Joint Principal Investigators of the project |
Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon |
| 5 | Website/Portal (Helpdesk) | Queries regarding NDLI and its services | support@ndl.gov.in |
| 6 | Contents and Copyright Issues | Queries related to content curation and copyright issues | content@ndl.gov.in |
| 7 | National Digital Library of India Club (NDLI Club) | Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach | clubsupport@ndl.gov.in |
| 8 | Digital Preservation Centre (DPC) | Assistance with digitizing and archiving copyright-free printed books | dpc@ndl.gov.in |
| 9 | IDR Setup or Support | Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops | idr@ndl.gov.in |
|
Loading...
|