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pH and reduction dual-responsive micelles based on novel polyurethanes with detachable poly(2-ethyl-2-oxazoline) shell for controlled release of doxorubicin
| Content Provider | Scilit |
|---|---|
| Author | Bu, Leran Zhang, Hena Xu, Kang Du, Baixiang Zhu, Caihong Li, Yuling |
| Copyright Year | 2019 |
| Description | We describe a biodegradable amphiphilic polyurethane (PU) with disulfide bonds in the main chain [PEtOz-b-PU(SS)-b-PEtOz]. This multi-block PU was synthesized using poly (ε-caprolactone) diol (PCL-SS-PCL) and poly (2-ethyl-2-oxazoline) (PEtOz-OH) as soft segments, and bis (2-isocyanatoethyl) disulfide as the hard segment. Acid-sensitive PEtOz-OH was used as a hydrophilic segment for pH sensitivity. And reduction sensitivity was induced via disulfide bonds incorporated into the hydrophobic poly (ε-caprolactone) segment of the amphiphilic PUs. The system can self-assemble to form micelles responsive to pH and reducing conditions. The properties of the micelle were studied with dynamic light scattering and scanning electron microscopy. Doxorubicin (DOX) was chosen as a model drug. The in vitro release studies showed that PEtOz-b-PU(SS)-b-PEtOz micelle could degrade more rapidly and completely in a reductive and acidic environment [10 mM dl-Dithiothreitol, pH 5.0]. The methyl tetrazolium (MTT) assay and fluorescent microscopy confirmed the cytotoxicity of the DOX-loaded micelles. This work provides a promising dual-responsive drug carrier based on amphiphilic PU to achieve efficient drug delivery. |
| Related Links | https://www.tandfonline.com/doi/pdf/10.1080/10717544.2019.1580323?needAccess=true https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442156/pdf |
| Ending Page | 308 |
| Page Count | 9 |
| Starting Page | 300 |
| ISSN | 10717544 |
| e-ISSN | 15210464 |
| DOI | 10.1080/10717544.2019.1580323 |
| Journal | Drug delivery |
| Issue Number | 1 |
| Volume Number | 26 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 2019-01-01 |
| Access Restriction | Open |
| Subject Keyword | Pharmacology and Pharmacy Polyurethane Micelle Dual- Responsive Poly(2-ethyl-2-oxazoline) Drug Delivery |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine Pharmaceutical Science |
