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| Content Provider | Royal Society of Chemistry (RSC) |
|---|---|
| Author | Liu, Ye Cheng, Weiren Kumar, Jatin N. Zhang, Yong |
| Copyright Year | 2015 |
| Abstract | Vinyl-terminated hyperbranched poly(amido amine)s is obtained by Michael addition polymerization of 4-(aminomethyl)piperidine (AMPD) with a double molar N,N-cystaminebis(acrylamide) (BAC). Then an amphiphilic hyperbranched poly(BAC2-AMPD1)-PEG is produced via converting the vinyl groups to amines followed by PEGylation. Transmission electron microscopy (TEM), dynamic light scattering (DLS), and 1H nuclear magnetic resonance (NMR) results indicate that the micelles can be obtained via self-assembly of hyperbranched poly(BAC2-AMPD1)-PEG. Further an anti-cancer drug, doxorubicin (DOX), can be loaded into the micelles. pH- and redox-response of the micelles of hyperbranched poly(BAC2-AMPD1)-PEG without and with DOX are investigated. The results of confocal microscopy and flow cytometry reflect that FITC tagged or DOX loaded micelles of hyperbranched poly(BAC2-AMPD1)-PEG can enter HepG2 and MCF-7 cells, and DOX can be observed in the nucleus of the cells. The cytotoxicity of the micelles without and with DOX is evaluated in HepG2 and MCF-7 cells, and the efficacy to kill the cancer cells is discussed in comparison with free DOX. |
| Starting Page | 597 |
| Ending Page | 607 |
| Page Count | 11 |
| File Format | HTM / HTML PDF |
| ISSN | 20474830 |
| Volume Number | 3 |
| Issue Number | 4 |
| Journal | Biomaterials Science |
| DOI | 10.1039/c4bm00410h |
| Language | English |
| Publisher | Royal Society of Chemistry |
| Access Restriction | Open |
| Subject Keyword | Fluorescein isothiocyanate Flow cytometry MCF-7 Confocal microscopy Cytotoxicity Concentration Doxorubicin Acrylamide FITC Self-assembly Chain-growth polymerization PEGylation Transmission electron microscopy Dynamic light scattering Michael PH Amphiphile Nuclear magnetic resonance Piperidine Cancer |
| Content Type | Text |
| Resource Type | Article |
| Subject | Materials Science Biomedical Engineering |
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