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Journal of Materials Chemistry B Vol - 2 Issue - 6

Journal of Materials Chemistry B Vol - 2 Issue - 5

Journal of Materials Chemistry B Vol -1

Blood compatibility and interaction with endothelial cells of titanium modified by sequential immobilization of poly (ethylene glycol) and heparin

Content Provider	Royal Society of Chemistry (RSC)
Author	Hou, Yan-Hua Ding, Hong-Yan Dong, Yun-Xiao Zhang, Bin-Bin Pan, Chang-Jiang
Copyright Year	2014
Abstract	In this study, poly(ethylene glycol) (PEG) and heparin were sequentially immobilized on a titanium surface by the carbodiimide covalent coupling method with the aim to improve the blood compatibility of titanium and enhance endothelial cell adhesion and proliferation. The results of attenuated total reflectance Fourier transform infrared spectroscopy (ATR-FTIR) and X-ray photoelectron spectroscopy (XPS) confirmed that PEG and heparin were successfully immobilized on the titanium surface. Compared to the pristine titanium, a highly hydrophilic layer was achieved after the immobilization, and the resulting heparin–PEG layer can significantly prevent human plasma fibrinogen adsorption. Analysis of platelet attachment to the modified surfaces, via scanning electron microscopy (SEM), showed strikingly fewer platelets attached to the PEG and heparin modified surfaces, compared to the control. The immobilized PEG and heparin effectively prolonged the activated partial thromboplastin time (APTT) and inhibit platelet activation significantly. Furthermore, the modified samples showed good cytocompatibility. Endothelial cells exhibited improved proliferative profiles in terms of a CCK-8 assay, as compared to those on the pristine titanium. The modified samples showed a better endothelial cell adhesion and spreading, than the pristine titanium. Therefore, the blood compatibility and cytocompatibility of the titanium surface can be enhanced by PEG immobilization and further, by subsequent heparin grafting. It could be concluded that the negatively charged heparin–PEG layer with excellent hydrophilicity could obviously improve the blood compatibility and enhance the endothelial cell adhesion and proliferation, and the approach of the present study is considered as an effective method to improve the hemocompatibility and cytocompatibility of biomaterials.
Starting Page	892
Ending Page	902
Page Count	11
File Format	HTM / HTML PDF
ISSN	2050750X
Volume Number	2
Issue Number	7
Journal	Journal of Materials Chemistry B
DOI	10.1039/c3tb21403f
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Ethylene glycol Heparin Titanium Carbodiimide Covalent bond Endothelium Attenuated total reflectance Fourier-transform infrared spectroscopy X-ray photoelectron spectroscopy Photoemission spectroscopy Hydrophile Blood plasma Fibrinogen Adsorption Platelet Scanning electron microscope Partial thromboplastin time Grafting Biomaterial
Content Type	Text
Resource Type	Article
Subject	Chemistry Medicine Materials Science Biomedical Engineering

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