NDLI: Heparin functionalisation of porous PLGA scaffolds for controlled, biologically relevant delivery of growth factors for soft tissue engineering

Please wait, while we are loading the content...

Design, crystal structures and enhanced frequency-upconverted lasing efficiencies of a new series of dyes from hybrid of inorganic polymers and organic chromophores

Site preference of Eu²⁺ dopants in the (Ba,Sr)_13−xAl_22−2xSi_10+2xO₆₆ phosphor and its effect on the luminescence properties: a density functional investigation

Revisiting the chemistry of graphite oxides and its effect on ammonia adsorption

Efficient hydrogen production using Cu-based catalysts prepared via homogeneous precipitation

In situ functionalization of mesoporous silica within the pores of anodic alumina membranes

Polar derivatives of the [closo-1-CB₉H₁₀]⁻ cluster as positive Δε additives to nematic hosts

Effects of bond character on the electronic structure of brownmillerite-phase oxides, Ca₂B′_xFe_2−xO₅ (B′ = Al, Ga): an X-ray absorption and electron energy loss spectroscopic study

Synthesis, mesomorphism and electronic properties of nonaflate and cyano-substituted pentyloxy and 3-methylbutyloxy triphenylenes

Localized surface plasmon resonance sensor based on Ag-PVA nanocomposite thin films

The nature of cobalt species in carbon nanotubes and their catalytic performance in Fischer–Tropsch reaction

Microwave-assisted synthesis of ZnO micro-javelins

Growth of ZnO nanotube arrays and nanotube based piezoelectric nanogenerators

Heparin functionalisation of porous PLGA scaffolds for controlled, biologically relevant delivery of growth factors for soft tissue engineering

Covalent-adsorption induced magnetism in graphene

Back matter

Back cover

Journal of Materials Chemistry Vol - 19 Issue - 39

Journal of Materials Chemistry Vol - 19 Issue - 29

Journal of Materials Chemistry Vol - 19 Issue - 19

Journal of Materials Chemistry Vol - 19 Issue - 9

Journal of Materials Chemistry Vol - 19 Issue - 8

Journal of Materials Chemistry Vol - 19 Issue - 7

Journal of Materials Chemistry Vol - 19 Issue - 6

Journal of Materials Chemistry Vol - 19 Issue - 5

Journal of Materials Chemistry Vol -9

Journal of Materials Chemistry Vol -8

Journal of Materials Chemistry Vol -7

Journal of Materials Chemistry Vol -6

Journal of Materials Chemistry Vol -5

Journal of Materials Chemistry Vol -4

Journal of Materials Chemistry Vol -3

Heparin functionalisation of porous PLGA scaffolds for controlled, biologically relevant delivery of growth factors for soft tissue engineering

Content Provider	Royal Society of Chemistry (RSC)
Author	Cameron, Neil R. Southgate, Jennifer Baker, Simon C. Rohman, Géraldine
Copyright Year	2009
Abstract	Non-specific protein adsorption has a major confounding influence on the in vitro and in vivo performances of synthetic polymer scaffolds for tissue engineering. For control over cell phenotype to be realised, non-specific protein adsorption needs to be constrained and surfaces modified by immobilisation of specific cell attachment and bioactive molecules. Our aim was to develop biodegradable scaffolds incorporating specific bioactive functionalities, whilst at the same time limiting non-specific protein adsorption by the polymer. The approach we developed was to functionalise PLGA scaffolds with diamino-terminated poly(ethylene glycol) (diamino-PEG), followed by the grafting of heparin to the free –NH2group at the PEG chain end using a coupling agent. The covalent grafting of poly(ethylene glycol) chains both suppressed non-specific protein attachment and provided a substrate for grafting of heparin, onto which growth factors could be tethered and presented to cells in a bioactive configuration. This approach offers a widely applicable solution to overcome the serious and confounding problem of serum fouling of scaffold surfaces, whilst also providing a generic route for specific biofunctionalisation.
Starting Page	9265
Ending Page	9273
Page Count	9
File Format	HTM / HTML PDF
ISSN	09599428
Volume Number	19
Issue Number	48
Journal	Journal of Materials Chemistry
DOI	10.1039/b911625g
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	PLGA Protein Adsorption Polymer Tissue engineering Phenotype Biodegradation Ethylene glycol Skin grafting Heparin Covalent bond Biofunctionalisation
Content Type	Text
Resource Type	Article
Subject	Chemistry Materials Chemistry

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

High mechanical strength chitosan-based hydrogels cross-linked with poly(ethylene glycol)/polycaprolactone micelles for the controlled release of drugs/growth factors

Dual physical dynamic bond-based injectable and biodegradable hydrogel for tissue regeneration

Blood compatibility and interaction with endothelial cells of titanium modified by sequential immobilization of poly (ethylene glycol) and heparin

Polymer–protein conjugates: an enzymatic activity perspective

A rheological study of biodegradable injectable PEGMC/HA composite scaffolds

Multi-material stereolithography: Spatially-controlled bioactive poly(ethylene glycol) scaffolds for tissue engineering

Synthesis and characterization of PLGA nanoparticle/4-arm-PEG hybrid hydrogels with controlled porous structures

Formation of bioactive highly porous polymer matrixes for tissue engineering

FDA-approved poly(ethylene glycol)–protein conjugate drugs

Heparin functionalisation of porous PLGA scaffolds for controlled, biologically relevant delivery of growth factors for soft tissue engineering

Similar Documents

High mechanical strength chitosan-based hydrogels cross-linked with poly(ethylene glycol)/polycaprolactone micelles for the controlled release of drugs/growth factors

Dual physical dynamic bond-based injectable and biodegradable hydrogel for tissue regeneration

Blood compatibility and interaction with endothelial cells of titanium modified by sequential immobilization of poly (ethylene glycol) and heparin

Polymer–protein conjugates: an enzymatic activity perspective

A rheological study of biodegradable injectable PEGMC/HA composite scaffolds

Multi-material stereolithography: Spatially-controlled bioactive poly(ethylene glycol) scaffolds for tissue engineering

Synthesis and characterization of PLGA nanoparticle/4-arm-PEG hybrid hydrogels with controlled porous structures

Formation of bioactive highly porous polymer matrixes for tissue engineering

FDA-approved poly(ethylene glycol)–protein conjugate drugs

Heparin functionalisation of porous PLGA scaffolds for controlled, biologically relevant delivery of growth factors for soft tissue engineering