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Journal of Materials Chemistry B Vol - 2 Issue - 6

Journal of Materials Chemistry B Vol - 2 Issue - 5

Journal of Materials Chemistry B Vol -1

Highly crystallized iron oxide nanoparticles as effective and biodegradable mediators for photothermal cancer therapy

Content Provider	Royal Society of Chemistry (RSC)
Author	Zhang, Jiaming Sun, Duxin Chen, Hongwei Burnett, Joseph Zhang, Fuxiang Paholak, Hayley
Copyright Year	2014
Abstract	We report that highly crystallized iron oxide nanoparticles (HCIONPs) made by thermal decomposition and further coating with a polysiloxane-containing copolymer can be used as effective mediators for photothermal therapy. Irradiation of a HCIONP solution containing 0.5 mg mL−1 Fe, for instance, with an 885 nm diode laser at a power of 2.5 W cm−2, induces a temperature increase of 33 °C from room temperature, while water produced only a ∼3 °C increase as the control. In vivo studies are further evaluated for effective photothermal therapy using the as-prepared HCIONPs. Benefiting from the great antibiofouling property of the polymer coating and minimized hydrodynamic size (whole particle size: 24 nm), the nanoparticles intravenously administered to SUM-159 tumor-bearing mice can effectively accumulate within the tumor tissue (5.3% of injection dose) through the enhanced permeability and retention effect. After applying the same laser conditions to irradiate the tumors, complete tumor regression is observed within three weeks without disease relapse over the course of three months. Conversely, control mice exhibit continuous tumor growth leading to animal mortality within four weeks. To better understand the photothermal effect of HCIONPs and potentially improve their photothermal efficiency, we compare their photothermal effect and crystal structures with commercially available magnetic nanoparticles. Our data show that after applying the same laser to commercially available magnetic nanoparticles from FeREX at the same iron concentration, the temperature is only increased by 7.4 °C. We further use synchrotron-XRD and high-resolution TEM to compare the crystal structures of both magnetic nanoparticles. The data show that both magnetic nanoparticles are Fe3O4 but as-prepared HCIONPs are highly crystalline and have preferred lattice plane orientations, which may be the cause of their enhanced photothermal efficiency. Taken together, these data suggest that HCIONPs, with unique lattice orientations and small size as well as antifouling coating, can be used as promising mediators for photothermal cancer therapy.
Starting Page	757
Ending Page	765
Page Count	9
File Format	HTM / HTML PDF
ISSN	2050750X
Volume Number	2
Issue Number	7
Journal	Journal of Materials Chemistry B
DOI	10.1039/c3tb21338b
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Iron oxide Copolymer Irradiation Diode Laser Polymer Permeation Linear regression Transmission electron microscopy Crystal structure Cancer
Content Type	Text
Resource Type	Article
Subject	Chemistry Medicine Materials Science Biomedical Engineering

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