NDLI: Quantification of protein adducts of hexahydrophthalic anhydride and methylhexahydrophthalic anhydride in human plasma

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Journal of Environmental Monitoring Vol - 2 Issue - 1

Quantification of protein adducts of hexahydrophthalic anhydride and methylhexahydrophthalic anhydride in human plasma

Content Provider	Royal Society of Chemistry (RSC)
Author	Rosqvist, Seema Lindh, Christian H. Johannesson, Gunvor Jönsson, B. A. G.
Copyright Year	2000
Abstract	Hexahydrophthalic anhydride (HHPA) and methylhexahydrophthalic anhydride (MHHPA) are two highly allergenic compounds used in the chemical industry. A method was developed for quantification of protein adducts of HHPA and MHHPA in human plasma. The plasma was dialysed and the anhydrides were hydrolysed from the proteins at mild acidic conditions. The released hexahydrophthalic acid (HHP acid) and methylhexahydrophthalic acid (MHHP acid) were purified by reversed solid phase extraction followed by derivatisation with pentafluorobenzyl bromide. The derivatives were analysed using GC-MS in negative ion chemical ionisation mode with ammonia as moderating gas. As internal standards, deuterium labelled HHP and MHHP acids were used. The detection limits were 0.06 pmol mL−1 plasma for HHP acid and 0.03 pmol mL−1 plasma for MHHP acid. The between-day precisions for HHP acid were 18% at 0.3 pmol mL−1 and 8% at 4 pmol mL−1. For MHHP acid, the precisions were 13% at 0.3 pmol mL−1 and 9% at 4 pmol mL−1. There were strong correlations (r = 0.94 for HHPA and 0.99 for MHHPA) between total plasma protein adduct concentrations and serum albumin adduct levels. Workers exposed to time-weighted average air levels of HHPA between <1 and 340 µg m−3 and between 2 and 160 µg m−3 for MHHPA had plasma adduct levels between the detection limits of the methods and 8.40 and 19.0 pmol mL−1, respectively.
Starting Page	155
Ending Page	159
Page Count	5
File Format	HTM / HTML PDF
ISSN	14640325
Volume Number	2
Issue Number	2
Journal	Journal of Environmental Monitoring
DOI	10.1039/a909714g
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Organic acid anhydride Chemical industry Protein Blood plasma Acid Hip Hop Pantsula Solid phase extraction Bromide Gas chromatography\u2013mass spectrometry Ion Ammonia Deuterium Blood proteins Adduct Serum albumin
Content Type	Text
Resource Type	Article
Subject	Public Health, Environmental and Occupational Health Management, Monitoring, Policy and Law

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