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| Content Provider | Royal Society of Chemistry (RSC) |
|---|---|
| Author | Wei, Chuanbao Ke, Chunlin Zeng, Xiaoxiong Qiao, Deliang |
| Copyright Year | 2015 |
| Abstract | Anti-angiogenic activities of crude Hyriopsis cumingii polysaccharides (HCPS) and its purified fractions (HCPS-1, HCPS-2 and HCPS-3) were evaluated in vivo using the chicken embryo chorioallantoic membrane (CAM) assay. The promoting effects of crude HCPS and its purified fractions on the chemotaxis, proliferation and phagocytosis of peritoneal macrophage were tested by cell model in vitro and cyclophosphamide-induced immuno-suppression animal model in vivo. The results showed that HCPS could significantly suppress the neovascularization of chicken embryo CAM and promote peritoneal macrophage migrating to monocyte chemotactic protein-1 (MCP-1), propagating and devouring sheep red blood cell (SRBC) in a dose-dependent manner. In addition, HCPS-3 showed stronger immunostimulatory activities in vitro than crude HCPS, HCPS-1 and HCPS-2. The beneficial effects of HCPS on the immune system might be, at least in part, attributed to the improvement of chemotaxis, proliferation and phagocytosis of peritoneal macrophage. All these results suggest that HCPS is a potential immunoenhancing and anti-tumor agent. |
| Starting Page | 869 |
| Ending Page | 877 |
| Page Count | 9 |
| File Format | HTM / HTML PDF |
| ISSN | 20426496 |
| Volume Number | 6 |
| Issue Number | 3 |
| Journal | Food & Function |
| DOI | 10.1039/c4fo01121j |
| Language | English |
| Publisher | Royal Society of Chemistry |
| Access Restriction | Open |
| Subject Keyword | Chicken Embryo Chorioallantoic membrane Chemotaxis Phagocytosis Macrophage Immunosuppression Model organism Neovascularization Monocyte Protein Red blood cell Immune system |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine Food Science |
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