NDLI: Hypoglycemic and hypolipidemic effects of neohesperidin derived from <i>Citrus aurantium</i> L. in diabetic KK-A<sup>y</sup> mice

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Hypoglycemic and hypolipidemic effects of neohesperidin derived from Citrus aurantium L. in diabetic KK-A^y mice

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Back cover

Food & Function Vol - 6 Issue - 2

Food & Function Vol -5

Food & Function Vol -4

Food & Function Vol -3

Food & Function Vol -2

Food & Function Vol -1

Hypoglycemic and hypolipidemic effects of neohesperidin derived from Citrus aurantium L. in diabetic KK-A^y mice

Content Provider	Royal Society of Chemistry (RSC)
Author	Chen, Kunsong Chen, Yanhong Zhao, Xiaoyong Hu, Ying Li, Xian Sun, Chongde Zhang, Wenna Jia, Sheng
Copyright Year	2015
Abstract	The present study is to investigate the possible hypoglycemic and hypolipidemic effects of neohesperidin (NHP) derived from Citrus aurantium L. in vivo. KK-Ay mice were used as the diabetic experimental model, whereas C57BL/6 mice were used as normal control for a 6-week study. Treatment of NHP significantly decreased fasting glucose, serum glucose, and glycosylated serum protein (GSP) in KK-Ay mice. It significantly elevated oral glucose tolerance and insulin sensitivity and decreased insulin resistance in the diabetic mice. In addition, NHP significantly decreased serum triglycerides (TG), total cholesterol (TCH), leptin level, and liver index in the KK-Ay mice. NHP also inhibited lipid accumulation in the liver and decreased the size of epididymal adipocyte in the KK-Ay mice. Gene expression of stearoyl-CoA desaturase 1 (SCD-1) and fatty acid synthase (FAS) were significantly inhibited, whereas the expression of acyl-CoA oxidase (ACOX) was significantly induced by NHP treatment in the liver of KK-Ay mice. In addition, elevated level of phosphorylation of hepatic AMPK was observed in NHP-treated mice. Therefore, the activation of the AMPK pathway and regulation of its target genes, including SCD-1, FAS, and ACOX, may play important roles in the hypoglycemic and hypolipidemic effects of NHP in vivo, and NHP may have great potential in the prevention of diabetes and its complications.
Starting Page	878
Ending Page	886
Page Count	9
File Format	HTM / HTML PDF
ISSN	20426496
Volume Number	6
Issue Number	3
Journal	Food & Function
DOI	10.1039/c4fo00993b
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	NHP AMPK Blood sugar Lipid-lowering agent Neohesperidin Horsepower Bitter orange Fasting Glucose Glycosylation Protein Impaired glucose tolerance Insulin Insulin resistance Triglyceride Cholesterol Leptin Liver Lipid metabolism Adipocyte Gene expression Stearoyl-CoA Fatty acid Fatty acid synthase Acyl-CoA oxidase Phosphorylation AMP-activated protein kinase Diabetes mellitus type 2
Content Type	Text
Resource Type	Article
Subject	Medicine Food Science

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Hypoglycemic and hypolipidemic effects of neohesperidin derived from Citrus aurantium L. in diabetic KK-A^y mice