NDLI: Lutein derived fragments exhibit higher antioxidant and anti-inflammatory properties than lutein in lipopolysaccharide induced inflammation in rats

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Lutein derived fragments exhibit higher antioxidant and anti-inflammatory properties than lutein in lipopolysaccharide induced inflammation in rats

Content Provider	Royal Society of Chemistry (RSC)
Author	Ramaprasad, Talahalli R. Sharavana, Gurunathan Vallikannan, Baskaran Nidhi, Bhatiwada
Copyright Year	2015
Abstract	In the present study, we appraise the anti-inflammatory efficacy of lutein oxidative degradation derivatives mediated through UV-irradiation over lutein in counteracting the inflammation induced by lipopolysaccharide (LPS) in rats (n = 5 per group). UV-irradiated lutein fragments were identified as anhydrolutein (B, C40H54O), 2,6,6-trimethylcyclohexa-1,4-dienylium (M1, C9H13), (2E,4E,6E,8E)-9-(4-hydroxy-2,6,6-trimethylcyclohex-1-1en-1-yl)-3,7-dimethylnona-2,4,6,8-tetraen-1-ylium (M2, C20H29O), 4-[(1E,3E,5E,7E)-3,7,-dimethyldeca-1,3,5,7-tetraen-1-yl]-3,5,5-methylcyclohex-3-en-1-ol (M3, C21H30O) and zeaxanthin (M4, C40H56O) and its isomers as 13′-Z zeaxanthin, 13′-Z lutein, all-trans zeaxanthin, and 9-Z lutein. Induction of inflammation by LPS significantly increased the production of nitrites (3.3 fold in the serum and 2.6 fold in the liver), prostaglandin E2 (26 fold in the serum), and pro-inflammatory cytokines like tumor necrosis factor-α (6.6 fold in the serum), and interleukin-6 (4.8 fold in the serum). Oxidative derivatives of lutein, especially M1, M2 and M3, ameliorated acute inflammation in rats by inhibiting the production of nitrites, malondialdehyde (MDA), PGE2, TNF-α, and IL-6 cytokines more efficiently than lutein in rats. The anti-inflammatory mechanism of derivatives might be related to the decrease of inflammatory cytokines and the increase of antioxidant enzymes (superoxide dismutase, catalase, glutathione peroxidase, glutathione S transferase, glutathione reductase), which would result in the reduction of iNOS, COX-2 and MDA and subsequently inflammatory responses.
Starting Page	450
Ending Page	460
Page Count	11
File Format	HTM / HTML PDF
ISSN	20426496
Volume Number	6
Issue Number	2
Journal	Food & Function
DOI	10.1039/c4fo00606b
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	MDA Inflammation Lipopolysaccharide Bazooka Leica M3 Zeaxanthin M4 carbine Liver Prostaglandin Tumor necrosis factor alpha Interleukin 6 Malondialdehyde Antioxidant Superoxide dismutase Catalase Glutathione peroxidase Glutathione Transferase Glutathione reductase Cyclooxygenase
Content Type	Text
Resource Type	Article
Subject	Medicine Food Science

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