NDLI: <i>Lactobacillus rhamnosus</i> LA68 and <i>Lactobacillus plantarum</i> WCFS1 differently influence metabolic and immunological parameters in high fat diet-induced hypercholesterolemia and hepatic steatosis

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Lactobacillus rhamnosus LA68 and Lactobacillus plantarum WCFS1 differently influence metabolic and immunological parameters in high fat diet-induced hypercholesterolemia and hepatic steatosis

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Food & Function Vol -5

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Lactobacillus rhamnosus LA68 and Lactobacillus plantarum WCFS1 differently influence metabolic and immunological parameters in high fat diet-induced hypercholesterolemia and hepatic steatosis

Content Provider	Royal Society of Chemistry (RSC)
Author	Minic, Rajna Skodric, Sanja Radojevic Djordjevic, Brizita Dimitrijevic, Ljiljana Zivkovic, Irena Ivanovic, Nevena
Copyright Year	2015
Abstract	In this study, two Lactobacillus strains (L. rhamnosus LA68 and L. plantarum WCFS1) were evaluated for their effects on high fat diet induced pathology in mice. The aim was to determine whether the administration of lactic acid bacteria had beneficial effects on ameliorating pathology. C57BL/6 mice fed a high fat diet were orally administered with the Lactobacillus strains. Both the metabolic and immunological parameters were analyzed. The administration of both of the strains had beneficial effects on mouse weight, serum cholesterol, TNF-α levels and liver histology. LA68 lowered the total cholesterol and HDL levels more prominently, whereas WCFS1 was more potent in lowering the TG and LDL levels. Leptin and adiponectin levels were increased in all experimental groups to different extents. The administration of L. plantarum WCFS1 led to a marked increase in leptin levels, as well as an increase in CD3+CD4+ and CD3+CD8+ cells, and a decrease of CD25+ cells, and had a lowering effect on IL-6 production and cell metabolic activity. In conclusion, active administration of both Lactobacillus strains had a positive effect on HFD-induced pathology. Although both of the tested strains had beneficial effects, oral administration of WCFS1 increased leptin levels and had a more prominent immunomodulatory effect, which should be taken into consideration in case of humane usage.
Starting Page	558
Ending Page	565
Page Count	8
File Format	HTM / HTML PDF
ISSN	20426496
Volume Number	6
Issue Number	2
Journal	Food & Function
DOI	10.1039/c4fo00843j
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Lactobacillus Lactobacillus plantarum Adipose tissue Pathology Acid Gut flora Mouse Cholesterol Tumor necrosis factor alpha Liver Histology High-density lipoprotein Low-density lipoprotein Leptin Adiponectin CD3 T helper cell Cytotoxic T cell IL2RA Interleukin 6
Content Type	Text
Resource Type	Article
Subject	Medicine Food Science

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