NDLI: Effects of resveratrol on gut microbiota and fat storage in a mouse model with high-fat-induced obesity

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Food & Function Vol - 5 Issue - 5

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Effects of resveratrol on gut microbiota and fat storage in a mouse model with high-fat-induced obesity

Content Provider	Royal Society of Chemistry (RSC)
Author	Le, Guowei Sun, Jin Xia, Shufang Shi, Yonghui Tang, Xue Qiao, Yi
Copyright Year	2014
Abstract	Recent studies have investigated the anti-obesity effect of resveratrol, but the pathways through which resveratrol resists obesity are not clear. In the present study, we hypothesize that resveratrol exerts anti-obesity effects that are likely mediated by mechanisms of regulating gut microbes, and in turn, improving fat storage and metabolism. Gut microbes, glucose and lipid metabolism in high-fat diet (HF) mice in vivo are investigated after resveratrol treatment. Several biochemical markers are measured. Fluorescence in situ hybridization and flow cytometry are used to monitor and quantify the changes in gut microbiota. The key genes related to fat storage and metabolism in the liver and visceral adipose tissues are measured by real-time PCR. The results show that resveratrol (200 mg per kg per day) significantly lowers both body and visceral adipose weights, and reduces blood glucose and lipid levels in HF mice. Resveratrol improves the gut microbiota dysbiosis induced by the HF diet, including increasing the Bacteroidetes-to-Firmicutes ratios, significantly inhibiting the growth of Enterococcus faecalis, and increasing the growth of Lactobacillus and Bifidobacterium. Furthermore, resveratrol significantly increases the fasting-induced adipose factor (Fiaf, a key gene negatively regulated by intestinal microbes) expression in the intestine. Resveratrol significantly decreases mRNA expression of Lpl, Scd1, Ppar-γ, Acc1, and Fas related to fatty acids synthesis, adipogenesis and lipogenesis, which may be driven by increased Fiaf expression. The Pearson's correlation coefficient shows that there is a negative correlation between the body weight and the ratios of Bacteroidetes-to-Firmicutes. Therefore, resveratrol mediates the composition of gut microbes, and in turn, through the Fiaf signaling pathway, accelerates the development of obesity.
Starting Page	1241
Ending Page	1249
Page Count	9
File Format	HTM / HTML PDF
ISSN	20426496
Volume Number	5
Issue Number	6
Journal	Food & Function
DOI	10.1039/c3fo60630a
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Lpl Lactobacillus Resveratrol Obesity Adipocyte Metabolism Glucose Lipid metabolism Flow cytometry Microbiota Liver Polymerase chain reaction Dysbiosis Enterococcus faecalis Bifidobacterium Gene Gastrointestinal tract Messenger RNA Adipogenesis Lipogenesis Correlation and dependence
Content Type	Text
Resource Type	Article
Subject	Medicine Food Science

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