NDLI: The hypocholesterolemic effect of capsaicinoids in ovariectomized rats fed with a cholesterol-free diet was mediated by inhibition of hepatic cholesterol synthesis

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The hypocholesterolemic effect of capsaicinoids in ovariectomized rats fed with a cholesterol-free diet was mediated by inhibition of hepatic cholesterol synthesis

Content Provider	Royal Society of Chemistry (RSC)
Author	Chen, Zhongdao Liu, Xiong Zheng, Longhui Fang, Guoshan Zhang, Lei
Copyright Year	2013
Abstract	Previous studies showed that capsaicinoid supplementation favorably modifies the plasma lipoprotein profile. The present study investigated the effect of capsaicinoids on plasma lipids and gene expressions of key receptors and enzymes involved in cholesterol metabolism in ovariectomized (OVX) rats. OVX rats were fed with a cholesterol-free diet and orally administered 0 mg kg−1 bw (OVX-CON), 5 mg kg−1 bw (OVX-LD), 10 mg kg−1 bw (OVX-MD), and 15 mg kg−1 bw (OVX-HD) capsaicinoids daily for 28 days. As the capsaicinoids dose increased, body weight gain and concentrations of plasma triglyceride, total cholesterol, and low-density lipoprotein cholesterol, as well as total lipid accumulation were significantly decreased. In addition, the mRNA levels of hepatic 3-hydroxyl-3-methylglutaryl CoA reductase and cholesterol-7α-hydroxylase were down-regulated, whereas those of transient receptor potential vanilloid type-1, ileal apical sodium-dependent bile acid transporter, and intestinal bile acid binding protein were up-regulated. The excretion of small intestinal bile acid contents and fecal bile acid also decreased. These results suggest that capsaicinoids can prevent ovarian hormone deficiency-induced hypercholesterolemia by inhibiting the hepatic cholesterol synthesis.
Starting Page	738
Ending Page	744
Page Count	7
File Format	HTM / HTML PDF
ISSN	20426496
Volume Number	4
Issue Number	5
Journal	Food & Function
DOI	10.1039/c3fo30321g
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Blood plasma Lipoprotein Gene Cholesterol Metabolism Triglyceride Lipid Messenger RNA Hydroxy group Coenzyme A Transient receptor potential channel Acid Protein Hormone Hypercholesterolemia
Content Type	Text
Resource Type	Article
Subject	Medicine Food Science

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