NDLI: Gui-ling-gao, a traditional Chinese functional food, prevents oxidative stress-induced apoptosis in H9c2 cardiomyocytes

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Food & Function Vol - 4 Issue - 4

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Gui-ling-gao, a traditional Chinese functional food, prevents oxidative stress-induced apoptosis in H9c2 cardiomyocytes

Content Provider	Royal Society of Chemistry (RSC)
Author	Li, Fan Wang, Qing-Hua Wan, Chun-Wai Chan, Chi-On Chan, Shun-Wan Wu, Jian-Hong Mok, Daniel Kam-Wah Shu, Yuan-Lan
Copyright Year	2013
Abstract	Functional foods have become an increasingly popular alternative to prevent diseases and maintain body health status. Gui-ling-gao (GLG, also known as turtle jelly) is a well-known traditional functional food popular in Southern China and Hong Kong. This study aimed to investigate the antioxidative and anti-apoptotic effects of GLG, a traditional Chinese functional food, on preventing oxidative stress-induced injury in H9c2 cardiomyocytes. In this study, the antioxidative capacities of GLG were measured by using both a cell-free assay [2,2-diphenyl-1-(2,4,6-trinitrophenyl)hydrazyl assay] and biological methods [2,2′-azobis(2-amidinopropane)-induced haemolysis assay and H2O2-induced cell damage on H9c2 cardiomyocytes]. Additionally, the total phenolic content was measured using the Folin–Ciocalteu method. Furthermore, the anti-apoptotic effect of GLG was evaluated by nuclear staining and a DNA fragmentation assay. GLG was found to have good antioxidant activities and high total phenolic content. In H2O2-induced cell damage on H9c2 cells, GLG was demonstrated to ameliorate the apoptotic effects, such as nuclear condensations, increased intracellular caspase-3 activity and inter-nucleosomal DNA cleavage, induced by H2O2. The present study demonstrated for the first time that GLG possesses anti-apoptotic potential in vitro and this effect may be mediated, in part, by its antioxidative function. Additionally, the antioxidative capacities of GLG were proved both chemically and biologically. This study provides scientific evidence to prove the anecdotal health-beneficial claim that the consumption of GLG could help the body to handle endogenous toxicants such as free radicals.
Starting Page	745
Ending Page	753
Page Count	9
File Format	HTM / HTML PDF
ISSN	20426496
Volume Number	4
Issue Number	5
Journal	Food & Function
DOI	10.1039/c3fo30182f
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	GLG Folin Southern China Hong Kong Popular Alternative Guilinggao Functional food China Antioxidant Hemolysis Hydrogen peroxide DNA fragmentation Caspase DNA
Content Type	Text
Resource Type	Article
Subject	Medicine Food Science

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Gui-ling-gao, a traditional Chinese functional food, prevents oxidative stress-induced apoptosis in H9c2 cardiomyocytes