NDLI: Lychee pulp phenolics ameliorate hepatic lipid accumulation by reducing miR-33 and miR-122 expression in mice fed a high-fat diet

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Lychee pulp phenolics ameliorate hepatic lipid accumulation by reducing miR-33 and miR-122 expression in mice fed a high-fat diet

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Food & Function Vol - 8 Issue - 1

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Food & Function Vol -2

Food & Function Vol -1

Lychee pulp phenolics ameliorate hepatic lipid accumulation by reducing miR-33 and miR-122 expression in mice fed a high-fat diet

Content Provider	Royal Society of Chemistry (RSC)
Author	Deng, Yuanyuan Wei, Zhencheng Chi, Jianwei Huang, Fei Hou, Fangli Yan, Shijuan Zhang, Ruifen Su, Dongxiao Liu, Lei Zhang, Mingwei
Copyright Year	2017
Abstract	Dietary phenolics exhibit hypolipidemic activity by changing lipid metabolism-related microRNA (miRNA) expression. Quercetin 3-O-rutinoside-7-O-α-L-rhamnosidase (quercetin 3-rut-7-rha), rutin and (−)-epicatechin are the main phenolics in lychee (Litchi chinensis Sonn.) pulp. A previous study reported that quercetin 3-rut-7-rha and rutin had hypolipidemic effects. To elucidate these effects and the underlying molecular mechanisms of lychee pulp phenolics (LPPs), the hepatic mRNA and protein expression of lipid metabolism-related genes and their associated miRNAs were measured after ten weeks of treatment with a high-fat diet (HFD) alone or in combination with LPPs. The administration of LPPs significantly reduced the HFD-induced increase in serum total cholesterol and triglyceride levels but increased the HDL-c content. The mRNA and protein expression levels of hepatic adenosine triphosphate-binding cassette transporter A1 (ABCA1) and carnitine palmitoyltransferase 1a (CPT1a) were upregulated, while fatty acid synthase (FAS) mRNA and the corresponding protein expression levels were downregulated by LPPs. Furthermore, the expression levels of miR-33, which directly modulates ABCA1 and CPT1a, and miR-122, which indirectly regulates FAS, were downregulated in mouse hepatocytes. The repression of miR-33 and miR-122 is a possible molecular mechanism of the hypolipidemic effects of LPPs in the liver. Our results suggest a novel hypolipidemic mechanism of LPPs.
Starting Page	808
Ending Page	815
Page Count	8
File Format	HTM / HTML PDF
ISSN	20426496
Volume Number	8
Issue Number	2
Journal	Food & Function
DOI	10.1039/c6fo01507g
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Sonn Lipid-lowering agent Lipid MicroRNA Quercetin Rut (mammalian reproduction) Rutin Catechin Lychee Pierre Sonnerat Messenger RNA Protein Cholesterol Triglyceride Adenosine ABCA1 Carnitine Fatty acid Fatty acid synthase MiR-33 Mouse Hepatocyte Liver
Content Type	Text
Resource Type	Article
Subject	Medicine Food Science

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Lychee pulp phenolics ameliorate hepatic lipid accumulation by reducing miR-33 and miR-122 expression in mice fed a high-fat diet