NDLI: Mulberry water extract regulates the osteoblast/osteoclast balance in an ovariectomic rat model

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Mulberry water extract regulates the osteoblast/osteoclast balance in an ovariectomic rat model

Content Provider	Royal Society of Chemistry (RSC)
Author	Lee, Yi-Ru Lo, Chien-Sheng Hsu, Jeng-Dong Jao, Hsing-Yu Lee, Huei-Jane
Copyright Year	2016
Abstract	Mulberry has favorable antioxidant ability. Menopause is a major cause of osteoporosis in women, and it is partially associated with oxidative stress. Here, mulberry water extract (MWE) was fed to ovariectomic (OVX) rats to explore the potential effect of MWE on osteoporosis. The results revealed that plasma alkaline phosphatase (ALP) significantly decreased in the OVX rats after MWE administration for 8 weeks. Histological examination showed that the MWE increased the density of trabecular bone in the OVX rats. It also revealed that the MWE increases the expression of Runx2 and decreases that of the receptor activator of nuclear factor κB and its ligand in the OVX rats. This implies that MWE might regulate osteoblast differentiation and osteoclast proliferation. The MWE improved the antioxidant status by lowering the expression of heme oxygenase-1. In addition, the MWE increased the expression of osteocalcin, ALP, and bone morphogenetic protein-2 in an osteoblast cell line, MG-63. The present results imply that MWE has potential to decelerate osteoporosis in an experimental OVX rat model.
Starting Page	4753
Ending Page	4763
Page Count	11
File Format	HTM / HTML PDF
ISSN	20426496
Volume Number	7
Issue Number	12
Journal	Food & Function
DOI	10.1039/c6fo00852f
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	MWE Antioxidant Menopause Osteoporosis Oxidative stress Paper mulberry Blood plasma Alkaline phosphatase Bone Osteoblast Osteoclast Heme oxygenase Osteocalcin Bone morphogenetic protein 2 MG Cars
Content Type	Text
Resource Type	Article
Subject	Medicine Food Science

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