NDLI: Protective effects of prescription n-3 fatty acids against impairment of spatial cognitive learning ability in amyloid β-infused rats

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Molecular property–affinity relationship of the interaction between dietary polyphenols and bovine milk proteins

Structure of modified ε-polylysine micelles and their application in improving cellular antioxidant activity of curcuminoids

Is iron status associated with highly unsaturated fatty acid status among Canadian Arctic Inuit?

Protective effects of prescription n-3 fatty acids against impairment of spatial cognitive learning ability in amyloid β-infused rats

Cardioprotective properties of raw and cooked eggplant (Solanum melongena L)

Raspberry juice consumption, oxidative stress and reduction of atherosclerosis risk factors in hypercholesterolemic golden Syrian hamsters

Dietary vitamin K alleviates the reduction in testosterone production induced by lipopolysaccharide administration in rat testis

Bioavailability of hop-derived iso-α-acids and reduced derivatives

New insights on the interaction mechanism between tau protein and oleocanthal, an extra-virgin olive-oil bioactive component

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Protective effects of prescription n-3 fatty acids against impairment of spatial cognitive learning ability in amyloid β-infused rats

Content Provider	Royal Society of Chemistry (RSC)
Author	Katakura, Masanori Shahdat, Hossain Haque, Abdul Gamoh, Shuji Tozawa, Ryuichi Tanabe, Yoko Shido, Osamu Hashimoto, Michio
Copyright Year	2011
Abstract	Deposition of amyloid β peptide (Aβ) into the brain causes cognitive impairment. We investigated whether prescription pre-administration of n-3 fatty acids improves cognitive learning ability in young rats and whether it protects against learning ability impairments in an animal model of Alzheimer's disease that was prepared by infusion of Aβ1–40 into the cerebral ventricles of rats. Pre-administration of TAK-085 (highly purified and concentrated n-3 fatty acids containing eicosapentaenoic acid ethyl ester and docosahexaenoic acid ethyl ester) at 300 mg kg−1 day−1 for 12 weeks significantly reduced the number of reference memory errors in an 8-arm radial maze, suggesting that long-term administration of TAK-085 improves cognitive leaning ability in rats. After pre-administration, the control group was divided into the vehicle and Aβ-infused groups, whereas the TAK-085 pre-administration group was divided into the TAK-085 and TAK-085 + Aβ groups (TAK-085-pre-administered Aβ-infused rats). Aβ1–40 or vehicle was infused into the cerebral ventricle using a mini osmotic pump. Pre-administration of TAK-085 to the Aβ-infused rats significantly suppressed the number of reference and working memory errors and decreased the levels of lipid peroxide and reactive oxygen species in the cerebral cortex and hippocampus of Aβ-infused rats, suggesting that TAK-085 increases antioxidative defenses. The present study suggests that long-term administration of TAK-085 is a possible therapeutic agent for protecting against Alzheimer's disease-induced learning deficiencies.
Starting Page	386
Ending Page	394
Page Count	9
File Format	HTM / HTML PDF
ISSN	20426496
Volume Number	2
Issue Number	7
Journal	Food & Function
DOI	10.1039/c1fo00002k
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Amyloid beta Peptide Model organism Ventricular system Acid Ester Memory Maze Infusion pump Working memory Peroxide Reactive oxygen species Cerebral cortex Hippocampus Antioxidant
Content Type	Text
Resource Type	Article
Subject	Medicine Food Science

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Prescription omega-3 fatty acid-induced prevention of impairment of memory learning in amyloid-beta-infused rats associates with the decrease of amyloid-beta levels in detergent-insoluble membrane fractions

P1-149: The protective effect of dietary eicosapentaenoic acid on the impairment of spatial cognition learning ability in Amyloid β peptide 1-40-infused rats

Studies of the Effects of Central Administration of β-Amyloid Peptide (25–35): Pathomorphological Changes in the Hippocampus and Impairment of Spatial Memory

The Protective Effects of Zeaxanthin on Amyloid-β Peptide 1–42-Induced Impairment of Learning and Memory Ability in Rats

Pelargonidin exhibits restoring effects against amyloid β-induced deficits in the hippocampus of male rats.

Do ω-3 Fatty Acids Regulate Cerebral β Amyloid?

Protective Effects of Cyperus Rotundus Extract on Amyloid β-Peptide (1-40)-Induced Memory Impairment in Male Rats: A Behavioral Study.

Inhibition of neprilysin by infusion of thiorphan into the hippocampus causes an accumulation of amyloid Beta and impairment of learning and memory.

The plasma membrane redox system is impaired by amyloid β-peptide and in the hippocampus and cerebral cortex of 3xTgAD mice

Protective effects of prescription n-3 fatty acids against impairment of spatial cognitive learning ability in amyloid β-infused rats

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Prescription omega-3 fatty acid-induced prevention of impairment of memory learning in amyloid-beta-infused rats associates with the decrease of amyloid-beta levels in detergent-insoluble membrane fractions

P1-149: The protective effect of dietary eicosapentaenoic acid on the impairment of spatial cognition learning ability in Amyloid β peptide 1-40-infused rats

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Protective effects of prescription n-3 fatty acids against impairment of spatial cognitive learning ability in amyloid β-infused rats